October 8th 2024
Education and employment, social and emotional functioning, and healthcare access are notable factors influencing pain in sickle cell disease.
October 7th 2024
This retrospective analysis examined the current management of early and late anemia in a representative sample of the kidney transplant population in Spain.
Anemia is frequently observed in primary care patients with HF and is linked to worse prognosis and comorbidities, including cancer.
October 3rd 2024
An elevated social vulnerability index score was linked to increased mortality among patients with SCD in the 5-year CDC WONDER database.
October 2nd 2024
An analysis of NYC’s lead registry data from 2005 to 2019 revealed a potential association between sickle cell disease and childhood lead poisoning.
Hematology Month in Review: September 2024
This month in review highlights vitamin D supplementation in anemia, the prevalence of iron deficiency in US adults, and the efficacy of rpFVIII in treating acquired hemophilia A.
Voxelotor for Sickle Cell Disease Recalled After Safety Concerns
Pfizer has announced the voluntary withdrawal of voxelotor in all markets after a report found the benefits do not outweigh the risks for sickle cell disease.
Iron Deficiency Extremely Common by Third Trimester of Pregnancy
A large study shows no women were anemic in the first trimester of pregnancy, but more than 80% of the women were iron deficient by the third trimester.
Absolute, Functional Iron Deficiency Affects Large Proportion of US Adults
Rates of absolute and functional iron deficiency were high among adults in the US, even in those without anemia, heart failure, or chronic kidney disease.
Vitamin D May Play Key Role in Anemia Prevention, Study Finds
New research establishes a strong causal link between elevated 25(OH)D levels and a reduced risk of anemia.
Intravenous Iron Outperforms Oral Tablets for Anemia in Pregnant Women
Ferric carboxymaltose achieved superior outcomes to an oral iron tablet for the treatment of anemia in pregnant women.
Pre-Pregnancy BMI Unrelated to Iron Deficiency During Pregnancy, Study Finds
Pre-pregnancy overweight and obesity were not linked to an increased prevalence of iron deficiency or anemia during pregnancy in a US population.
Real-World Data Support Use of rpFVIII for Acquired Hemophilia A
A real-world post-authorization safety study identified no new safety signals compared with the phase 2/3 clinical trial of rpFVIII for acquired hemophilia A.
Anemia Impacts Dependence in Daily Activities of Living for Older Women
An investigation into basic and instrumental activities of daily living in older female patients found greater reliance in those with anemia.
Study Reveals Research Gaps on Acute Pancreatitis in Sickle Cell Disease
A systematic review found a higher prevalence of acute pancreatitis in individuals with the HbSS genotype, though a meta-analysis could not be performed.
Daily Vadadustat Equal to Darbepoetin Alfa for Anemia in Dialysis-Dependent CKD
Vadadustat once-daily demonstrated noninferiority to darbepoetin alfa for the change in mean hemoglobin from baseline, while 3-times-weekly did not.
Hematology Month in Review: August 2024
This August 2024 month in review highlights new recommendations from the USPSTF, FDA approval of a treatment for chronic GVHD, and Phase 2 data for severe HDFN.
Anemia Increases Cardiac Arrest, Stroke Risk in COVID-19 Admissions
Moderate to severe anemia was linked to an increase in cardiac arrest or stroke compared with normal hemoglobin levels in critically ill COVID-19 patients.
Iron Deficiency Cases Persist Over 3 Years in Statewide Health System
Across a statewide cohort, more than half of patients were unable to achieve iron deficiency resolution within 3 years.
USPSTF: Iron Deficiency Screening, Supplementation in Pregnancy Lacks Evidence
A new recommendation statement cites a lack of current evidence to assess the benefits of iron deficiency screening and supplementation in pregnant individuals.
Grape Syrup Improves Iron Deficiency Anemia Parameters in Women
A randomized clinical trial found significant improvements in key blood parameters for anemia after grape syrup intervention compared with placebo.
Patient Reported Outcomes Favor Concizumab Prophylaxis in Hemophilia A or B
Analysis of the Phase 3 explorer7 study indicates a preference for concizumab prophylaxis over no prophylaxis in patients with hemophilia A or B with inhibitors.
FDA Approves Axatilimab for Chronic Graft-Versus-Host Disease
Axatilimab was awarded approval for the treatment of chronic GVHD in adult and pediatric patients who failed ≥2 prior lines of systemic therapy.
Ravulizumab Boosts Activity Levels, Quality of Life in Patients with PNH
Ravulizumab therapy may enable patients with PNH to achieve activity and patient-reported outcomes comparable to the US general population.
Disease Status Influences VTE Risk in Women with Sickle Cell Disease
Thrombotic risk is more likely influenced by disease status than hormonal contraception exposure in women with SCD.
Long-Term Quality of Life Remains Normal After HCT for Sickle Cell
Interim analysis of STELLAR showed health-related quality of life domains were within a normal range after hematopoietic cell transplant for SCD.
UNITY: Nipocalimab Improves Survival in Early-Onset Severe HDFN
Nipocalimab led to a substantially higher percentage of live births at 32 weeks’ gestation or later without intrauterine transfusions than the historical benchmark.
Ferritin Cutoff Choice Linked to Rates of Iron Deficiency Diagnosis
Ferritin cutoffs of 30 and 45 ng/mL notably increase the rate of iron deficiency diagnoses.
Emergency Department Use for Sickle Cell Declined at Onset of COVID-19
Emergency department utilization patterns in people with sickle cell disease were impacted by the onset of the COVID-19 pandemic in 4 US states.
Anemia Treatment Delays Not Linked to Renal Event Risk in CKD
Delayed anemia treatment with ESAs was not correlated with worse renal events but elevated the risk of cardiovascular events and all-cause mortality.
Anemia Linked to Adverse Outcomes After Percutaneous Coronary Intervention
Anemia is common in high-risk PCI and is independently associated with major adverse cardiovascular events and major bleeding risk.
Hematology Month in Review: July 2024
Our July 2024 hematology month in review examines the latest updates to the hematological pipeline and key study data informing clinical practice.
Sickle Cell Disease Linked to Higher Risk of Retinal Vascular Occlusion
Patients with hemoglobin SS sickle cell disease type may experience a significantly elevated risk of retinal vascular occlusion.
Male Sex, Younger Age Linked to Sickle Cell Retinopathy Progression
Patient factors trended towards an association with a higher risk of proliferative sickle cell retinopathy but did not reach statistical significance.
Hemophilia A Gene Therapy Displays Superiority in Phase 3 AFFINE Trial
Giroctocogene fitelparvovec achieved primary and key secondary objectives of superiority compared to routine prophylaxis in hemophilia A treatment.