July 25th 2024
Patient factors trended towards an association with a higher risk of proliferative sickle cell retinopathy but did not reach statistical significance.
July 24th 2024
Giroctocogene fitelparvovec achieved primary and key secondary objectives of superiority compared to routine prophylaxis in hemophilia A treatment.
July 19th 2024
A study found individuals with type 2 diabetes who received less than 7 hours of sleep had 2.6 increased odds of microvascular disease.
July 18th 2024
The XTEND-Kids phase 3 trial shows efanesoctocog alfa’s safety and efficacy in children with severe hemophilia A, reducing bleeds with once-weekly dosing.
July 14th 2024
A study from the ASH Research Network reports positive antibody response and tolerability after mRNA vaccination in people with sickle cell disease.
Anemia Diagnostic Tests Infrequent, Linked to Low Treatment Rates in CKD
Diagnostic tests for anemia etiology are infrequently ordered, leading to a significant majority of patients with CKD receiving inadequate treatment.
Mortality Risk Unchanged by Iron Dose in Hemodialysis Patients with Cancer
Iron administration did not increase the mortality risk of hemodialysis patients with cancer, but the safety of increasing ESA doses was not confirmed.
Anemia Increases Risk of End-Stage Kidney Disease in IgA Nephropathy
An analysis of more than 800 IgAN patients treated from 2002-2021 provides an overview of factors associated with anemia as well as its impact on prognosis.
SGLT2 Inhibitors Can Improve Anemia in Patients with CKD
Data from ERA 24 builds on previous research examining the effect of SGLT2 inhibitors on hemoglobin levels among patients with chronic kidney disease.
Smartphone App Accurate in Anemia Detection from Conjunctival Images
The smartphone app demonstrated higher accuracy, sensitivity, and specificity in patients with severe anemia than those with moderate anemia.
Intravenous Immunoglobulin May Benefit Severe Autoimmune Hemolytic Anemia
Retrospective data suggest the off-label use of IVIg could be helpful in the management of severe autoimmune hemolytic anemia.
Oral Liposomal Iron Helps Correct Iron Deficiency in Non-Dialysis CKD
Liposomal iron achieves a partial correction of transferrin saturation, with no significant effect on iron storage and hemoglobin, in patients with NDD-CKD.
Artificial Intelligence Algorithms Detect Anemia from Fundus Images
Automated anemia detection from fundus images may benefit patients undergoing routine retinal imaging.
FDA Clears IND Application for CID-103 in Immune Thrombocytopenia
Announced on May 15, 2024, the IND application supports a phase 1/2 study of CID among adults with chronic ITP.
Age, Genetics Help Predict Proliferative Sickle Cell Retinopathy
Age and sickle cell disease genotype predicted individuals with sickle cell retinopathy at risk for proliferative disease.
Anti-VEGF Improves Outcomes in Proliferative Sickle Cell Retinopathy
Within one month of treatment, anti-VEGF therapy improves anatomic and visual outcomes among eyes with stage 3 and 4 proliferative sickle cell retinopathy.
FDA Updates ALTUVIIIO Label with Full Pediatric Data in Hemophilia A
Announced by Sanofi on May 10, 2024, the updated FDA label is based on full results from the pivotal phase 3 XTEND-Kids study.
Hydroxyurea Dose Escalation Effective for Children with Sickle Cell Anemia
Extended follow-up of a phase 1/2 trial finds hydroxyurea dose optimization significantly improves clinical responses in children in sub-Saharan Africa with sickle cell.
Hematology Month in Review: April 2024
Our April month in review for hematology breaks down the latest updates to the pipeline, mortality risk in people with sickle cell disease, and our newest multimedia offerings.
Recombinant ADAMTS13 Prophylaxis Effective Approach for Congenital TTP
An interim analysis of a phase 3 trial displays the effectiveness of prophylaxis with recombinant ADAMTS13, achieving approximately 100% of normal ADAMTS13 levels.
SGLT2is, GLP-1s Display Reno-Protective Benefit in Sickle Cell Disease
Preliminary findings demonstrate an improvement in eGFR slope in nearly all patients with SCD after treatment with SGLT-2 inhibitors and GLP-1 receptor agonists.
Tricuspid Regurgitation Velocity Linked to Cerebrovascular, Kidney Disease in SCD
A higher TRV was significantly associated with cerebrovascular disease and persistent albuminuria in children with SCD across two large cohorts.
Rilzabrutinib Achieves Phase 3 Primary Endpoint in Immune Thrombocytopenia
Rilzabrutinib led to a durable platelet response in adult patients with persistent or chronic immune thrombocytopenia in the LUNA 3 study.
Patients with SCD Face Early Death Despite Improved Survival Rates
A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.
Presence of Anemia Negatively Impacts Long-Term Prognosis in HFmrEF
Anemia and iron deficiency are prevalent in heart failure with mildly reduced ejection fraction and may worsen mortality and rehospitalization outcomes.
Intravenous Iron Boosts Hemoglobin Levels in Children with Anemia, IBD
Treatment with intravenous iron therapy proves more efficacious than oral or no iron therapy in improving hemoglobin in pediatric patients admitted with IBD and IDA.
Frequent Hospitalized VOCs Worsens Mortality Risk in Sickle Cell Disease
In a nationwide study of an adult SCD population, the risk of mortality increased with the number of HVOCs in the year before death.
Current Diagnostics May Misclassify Suspected Heparin-Induced Thrombocytopenia
When the current recommended diagnostic algorithm was used in clinical practice, antibody testing was required in half of patients with suspected HIT.
Alternate-Day Iron May Be More Effective for Patients with Anemia, Diabetes
Oral iron supplements did not significantly differ in increasing hemoglobin and ferritin levels, but the every-other-day oral iron proved more effective than daily use.
Clinical Quiz: Gastrointestinal Evaluation of Iron Deficiency Anemia
This clinical quiz will test your knowledge of iron deficiency anemia, focused on the gastrointestinal evaluation of anemia based on recommendations from the AGA's 2020 guidelines.
Hematology Month in Review: March 2024
Our March 2024 month-in-review in hematology features updates to the anemia pipeline, the latest research in sickle cell disease, and the role of SGLT2 inhibition on hematologic outcomes.
Bitopertin Meets Primary Phase 2 Endpoint in Erythropoietic Protoporphyria
Topline results from AURORA indicate that while bitopertin significantly reduced PPIX levels, improvements in light tolerance were not statistically significant.
Intravenous Iron Increases Hemoglobin in Heart Failure Treated with SGLT2 Inhibition
Iron-deficient patients on an SGLT2 inhibitor at baseline experienced greater increases in hemoglobin levels with ferric derisomaltose compared with those not taking one.
Research Gaps Limit Role of Intravenous Hydration for Sickle Cell Crises
A systematic review highlights the available evidence on the use of intravenous fluid in sickle cell vaso-occlusive crises and reported adverse outcomes.
FDA Approves Vadadustat (Vafseo) Tablets for Anemia Due to CKD in Adult Patients on Dialysis
Vadadustat tablets are now approved for the treatment of anemia due to CKD in adults who have been receiving dialysis for ≥ 3 months.