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Expert endocrinologists explore the pathophysiology of type 1 diabetes (T1D) and delve into screening and staging processes. They discuss strategies for delaying its onset and provide insight into the future of T1D management.

Delaying the Onset of Type 1 Diabetes Through Early Intervention

Episodes

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EP. 1: Risk Factors and Triggers for Type 1 Diabetes (T1D)

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

July 19th 2023

Schafer Boeder, MD, discusses the incidence of type 1 diabetes, highlighting risk factors such as age and family history.

EP. 2: Pathophysiology of T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

July 19th 2023

Justin M. Gregory, MD, MSC, and Linda A. DiMeglio, MD, provide an overview of the pathophysiology of type 1 diabetes.

EP. 3: T1D Staging and Classification

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

July 26th 2023

Expert endocrinologists review the importance of staging and classifying T1D, highlighting dysglycemia.

EP. 4: Early Diagnosis of T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

July 26th 2023

Linda A. DiMeglio, MD, comments on the importance of early diagnosis of T1D, giving patients the advantage of preparing a treatment plan early.

EP. 5: Identifying Individuals at High Risk for T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 2nd 2023

Justin M. Gregory, MD, MSC, reviews the risk factors of T1D, highlighting a family history of T1D and antibody screening.

EP. 6: Clinical Signs Leading to Diagnostic Testing for T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 2nd 2023

Expert endocrinologists discuss the clinical symptoms that prompt testing for T1D, as well the diagnostic testing tools that are available in clinical practice.

EP. 7: T1D Screening Options

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 9th 2023

Linda A. DiMeglio, MD, reviews screening options for patients with a family history of T1D, highlighting TrialNet.

EP. 8: Interpreting T1D Antibody Test Results

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 9th 2023

Egils K. Bogdanovics, MD, and Schafer Boeder, MD, discuss interpreting antibody test results for type 1 diabetes and provide recommendations for retesting for those who have a negative test or have only 1 antibody present.

EP. 9: Use of Teplizumab in Delaying T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 16th 2023

Justin M. Gregory, MD, MSCI, provides an overview of the mechanism of action of teplizumab and its use in delaying T1D.

EP. 10: Efficacy of Teplizumab in Clinical Trials

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 16th 2023

Egils K. Bogdanovics, MD, and the expert panel review the TN10 study data on the efficacy of teplizumab in delaying the progression of T1D, which led to the drug’s approval from the FDA.

EP. 11: Long-Term Monitoring of Teplizumab in T1D

BySteve Edelman, MD,Linda A. DiMeglio, MD,Egils K. Bogdanovics, MD,Justin M. Gregory, MD, MSC,Schafer Boeder, MD

August 23rd 2023

Expert endocrinologists discuss implementing long-term monitoring of patients being treated with teplizumab for type 1 diabetes and review the PROTECT study for patients who are newly diagnosed with T1D.