Time as a Diagnostic Tool


The timing of the onset of a patient's symptoms can serve as a critical piece of the puzzle when trying to determine a diagnosis.

This article originally appeared online at DrPullen.com, part of the HCPLive Network.

I can’t remember which lecture it was, or even just when in my first two years of medical school the lecture was given, but I do remember how the concept struck me as really important. The gist of the message was that the timing of onset of a patient’s symptoms is a key part of understanding the nature of the patient’s diagnosis. Symptoms from a neoplasm come on gradually, tend to be persistant and progressively more intense. Symptoms of an infection tend to come on more quickly, evolving over hours to days, and usually becoming progressively worse at least initially. Symptoms of ischemia, i.e. of an organ not being perfused by freshly oxygenated arterial blood, tend to come on over a minute or more, last at least several minutes, and resolve gradually.

Understanding this natural timing of various types of processes can help differentiate the nature of symptoms. Fleeting chest pains that last a second or two almost never are related to coronary ischemia, because the heart muscle does not respond that quickly to lack of circulation, either in the onset of pain or the resolution of pain. A mass in the neck that comes up overnight is rarely a cancer, because cancer cells just don’t multiply that fast, whereas the inflammatory response to infection can lead to enlargement of lymph nodes very quickly. The headache from a ruptured cerebral aneurysm comes on suddenly, whereas a migraine headache builds up over minutes to hours.

Another use of time is to watch to see the progression of symptoms after a patient initially comes to the physician. Any times one of the decisions at the initial visit for a patient complaint is to decide between doing diagnostic testing right away, and waiting for a few days or weeks to see how the symptoms and physical findings progress. . This wait and see approach is sometimes the best approach to figuring out what is causing the problem, i.e. making a diagnosis. A good example of this is in the patient who comes complaining of a twisted knee with swelling. After initial assessment, and deciding that there is no emergent surgical problem, the options might be:

  1. Use ice, ibuprofen, an ace wrap, and rest along with gradually increasing activity and some exercises and to reevaluate the knee in 2 weeks.
  2. Send the patient for an x-ray and if no abnormalities get an MRI to see if there is a meniscus injury and to define the extent of ligamentous injury.

The big difference is often just cost and the desire to know what’s wrong, i.e. have a firm diagnosis, to avoid living with uncertainty for a while. When it’s OPM (other people’s money) as it is in our system much of the time, spending money to avoid living with uncertainty is very tempting. I don’t recall the last time an uninsured patient urged me to please quickly spend their own money to order an expensive test that had a good chance of being avoided by using time as a helpful diagnostic tool.

Patients intuitively use time in their decision making routinely. I often hear the comment, “I would not have come in for this nasal congestion, but it’s just gone on too long to be just a cold.” Similar comments with pain and swelling from ankle sprains, diarrhea, hives, pink eye, and similar problems bring patients in to see daily. Sometimes their concerns are also concerning to me as their physician, and warrant diagnostic evaluation or therapeutic intervention. Other times more time is needed to allow the self limited problem to run its natural course.

Time; you can’t buy any more of it, but it’s use as a diagnostic tool is often free.

Ed Pullen, MD, is a board-certified family physician practicing in Puyallup, WA. He blogs at DrPullen.com — A Medical Bog for the Informed Patient.

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