Fluoxetine Reduces Symptoms for Children with Autism Spectrum Disorders

Article

New data shows that selective serotonin reuptake inhibitors reduce obsessive-compulsive symptoms for children and adolescents with autism spectrum disorders.

Dinah S. Reddihough, MD

Dinah S. Reddihough, MD

Selective serotonin receptor inhibitors like fluoxetine are often prescribed to reduce the severity of core behaviors of autism spectrum disorders, but the efficacy of this treatment is currently unknown.

In a multicenter, randomized, placebo-controlled clinical trial, investigators led by Dinah S. Reddihough, MD, Royal Children’s Hospital, found that treatment with fluoxetine yielded significantly lower scores for obsessive-compulsive behaviors at 16 weeks.

The trial included 146 patients between 7.5-18-years old with autism spectrum disorders from 3 tertiary health centers in Australia and a total score of at least 6 on the Children’s Yale-Brown Obsessive Compulsive Scale-Modified for Pervasive Developmental Disorders (CYBOCS-PDD).

The participants were randomized to either receive fluoxetine (n=75) or placebo (n=71). The medication group received either 4 or 8 mg/d dosages for the first week, depending on their weight. They were then titrated to a maximum dose of 20 or 30 mg/d over 4 weeks. Overall, treatment duration was 16 weeks.

The dosage was also decreased for any patient who suffered from a significant adverse effect.

The investigators found that the fluoxetine group had a mean score of 9.02 points, while the placebo group had a mean score of 10.89 points, which was deemed statistically significant.

However, a prespecified analysis that accounted for potentially confounding factors and baseline was null.

“In this preliminary study of children and adolescents with autism spectrum disorders, treatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks,” the authors wrote. “Interpretation is limited by the high dropout rate, null findings of prespecified analyses that accounted for potentially confounding factors and baseline imbalances, and CIs for the treatment effect that included the minimal clinically important difference.”

The primary outcome of the study was the total score on the CYBOCS-PDD at 16 weeks post-randomization, analyzed with a linear regression model that was adjusted for stratification factors such as site, age at baseline, and intellectual disability, with an additional prespecified model that included additional adjustment for baseline score, sex, communication level, and imbalanced baseline and demographic variables.

The secondary outcomes included the difference between groups at 16 weeks in a number of different scales including the Repetitive Behavior Scale-Revised, Spence Children’s Anxiety Scale, Aberrant Behavior Checklist-Community Version, Clinical Global Impression Scale-Global Improvement and Efficacy Index, and Disruptiveness Assessment.

“The mean CYBOCS-PDD score from baseline to 16 weeks decreased in the fluoxetine group from 12.80 to 9.02 points (3.72-point decrease; 95% CI, −4.85-−2.60) and in the placebo group from 13.13 to 10.89 points (2.53-point decrease; 95% CI, −3.86-−1.19),” the authors wrote. “The between-group mean difference at 16 weeks was −2.01 (95% CI, −3.77-−.25; P = .03) (adjusted for stratification factors), and in the prespecified model with further adjustment, it was −1.17 (95% CI, −3.01-.67; P = .21).”

The most common adverse events were mood disturbance, particularly irritability, gastrointestinal problems such as nausea and diarrhea, and sleep disorders.

The study, “Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders,” was published online in JAMA.

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