As recently as 2015, over 30 million people in the US had diabetes—a rate equivalent to 9.4% of the US population.1 Of these cases, a rate of 90%-95% are type 2 diabetes (T2D).1 The prevalence of T2D has been on the rise.2
Patients are advised to work closely with their physicians to set and achieve long-term strategies, including diet modifications and improvements to exercise routines. Lifestyle management is a fundamental aspect of diabetes care and healthcare providers may recommend pharmacotherapy for patients when target blood sugar levels have not been achieved with diet and exercise alone.3,4 Diabetes care should be individualized for each patient, which may include determining the appropriate pharmacologic treatment.3
A significant milestone in the area of T2D therapies was the approval of the first glucagon-like peptide-1 receptor agonist (GLP-1 RA), in the U.S., in 2005.5 In 2017, the FDA approved the GLP-1 RA BYDUREON BCise® (exenatide extended-release)‎ injectable suspension 2 mg.6 Indicated for the lowering of glycated hemoglobin (HbA1c) as an adjunct to diet and exercise in adults with T2D who are uncontrolled on antidiabetic agent(s), BYDUREON BCise features convenient once-weekly dosing and an easy to use device for patients working to manage their T2D.7
Individualizing, Simplifying T2D Care
Medication adherence plays an essential role in overall glycemic control. Unfortunately, the adherence rate among patients with T2D is as low as 45%, with nearly one-third of patients with T2D failing to fill even their first prescription of a glucose-lowering agent.8,9
But more convenient options and advances in formulations and delivery devices may help improve adherence.10
One option for healthcare providers to consider is the single-dose autoinjector BYDUREON BCise. This once-weekly autoinjector device was deemed “easy” or “very easy” to use by 86% of patients in a clinical study.11 The non-insulin therapy was designed to be simple to use, being administered subcutaneously in 4 steps following preparation: mix, unlock, unscrew and inject. The injection contains a unique continuous-release microsphere technology that releases the medicine into the body over time, reaching a steady state at 10 weeks with continued once-weekly dosing.12 In turn, BYDUREON BCise helps the body release its own insulin to help lower blood sugar specifically when the body needs it.7
BYDUREON BCise is not recommended as a first therapy for type 2 diabetes and should not be used to treat type 1 diabetes. It causes an increased incidence in thyroid C-cell tumors at clinically relevant exposures in rats compared to controls. It is unknown whether BYDUREON BCise causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC) in humans, as the human relevance of exenatide extended-release-induced rodent thyroid C-cell tumors has not been determined. It is contraindicated in patients with a personal or family history of medullary thyroid cancer, or in patients with Multiple Endocrine Neoplasia syndrome type 2, or with a prior serious hypersensitivity reaction to any of the product components.7
The most common adverse reactions are injection site reaction (10.5%) and nausea (8.2%).7 Please refer to the IMPORTANT SAFETY INFORMATION below for more details.
Looking at the Future of T2D Care
Effective T2D medication therapy delivers the right drug at the right dose, through the right route, at the right time, for the right patient. Though the sheer breadth of available antihyperglycemic therapies—available across different drug classes, in combination or as lone therapy—is overwhelming, the base of knowledge informing treatment decisions is still growing.
Some decisions may be simplified by a proven, easy-to-use device such as BYDUREON BCise.
IMPORTANT SAFETY INFORMATION
WARNING: RISK OF THYROID C-CELL TUMORS
WARNINGS AND PRECAUTIONS
Most common (≥5%) in clinical trials: injection-site nodule (10.5%), nausea (8.2%).
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
INDICATION AND LIMITATIONS OF USE
BYDUREON BCise is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
1. Centers for Disease Control. National Diabetes Statistics Report, 2017. Atlanta, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2017.
https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf Last accessed July 25, 2019.
2. Centers for Disease Control. Long-Term Trends in Diabetes, April 2017.
https://www.cdc.gov/diabetes/statistics/slides/long_term_trends.pdf. Last accessed July 25, 2019.
3. American Diabetes Association. Standards of Medical Care in Diabetes — 2019. Diabetes Care. 2019;42(Suppl 1):S1-S55.
https://care.diabetesjournals.org/content/42/Supplement_1. Last accessed July 25, 2019.
4. Mayo Clinic. Type 2 Diabetes-Diagnosis & treatment.
https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/diagnosis-treatment/drc-20351199. Last accessed July 25, 2019.
5. Trujillo JM, Nuffer W, Ellis SL. GLP-1 receptor agonists: a review of head-to-head clinical studies. Ther Adv Endocrinol Metab. 2015;6(1):19-28.
6. AstraZeneca US press release. US FDA approves new easy-to-use, once-weekly BYDUREON® BCiseTM injectable medicine for patients with type-2 diabetes.
https://www.astrazeneca-us.com/content/az-us/media/press-releases/2017/us-fda-approves-new-easy-to-use-once-weekly-bydureon-bcise-injectable-medicine-for-patients-with-type-2-diabetes-10232017.html. Last accessed July 25, 2019.
7. BYDUREON BCise® ([exenatide extended-release] injectable suspension) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2019.
8. Curkendall SM, Thomas N, Bell KF, Juneau PL, Weiss AJ. Predictors of medication adherence in patients with type 2 diabetes mellitus. Curr Med Res Opin. 2013; 29:1275-1286.
9. Fischer MA, Stedman MR, Lii J, et al. Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25: 284-290.
10. Giorgino F, Penfornis A, Pechtner V, Gentilella R, Corcos A. Adherence to antihyperglycemic medications and glucagon-like peptide-1 receptor agonists in type 2 diabetes: clinical consequences and strategies for improvement. Patient Prefer Adherence. 2018;12:707-719.
11. Data on File, REF-14053, AstraZeneca Pharmaceuticals.
12. BYDUREON BCise HCP site. https://www.bydureonhcp.com/bydureon-bcise/pk-profile.html. Last accessed July 25, 2019.