Article
Take the quiz to see how much you know about SLE-related complications during pregnancy.
Systemic lupus erythematosus (SLE) is associated with a number of serious complications during pregnancy. Take this 5-question quiz to see how much you know.
Question 1.
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Answer: D. 20 times higher
A national study of complications of lupus in pregnancy retrospectively evaluated risks of maternal mortality from more than 16.7 million admissions for childbirth over 4 years; 13,555 of the admissions were for women with SLE. The rate of maternal mortality in women with SLE was 20-fold higher than among those without SLE.1
Question 2.
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Answer: E. All of the above
SLE is associated with a range of serious pregnancy complications that affect both fetal and maternal outcomes.2
Question 3.
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Answer: A. If they are in remission or have stable low disease activity
It is considered safe for women with SLE to plan a pregnancy when disease is in remission or disease activity is low and remains stable, although medications should be carefully reviewed and adjusted as necessary.2
Question 4.
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Answer: D. 4 to 6 months
A retrospective study showed that a waiting period of only 4 months (compared with earlier standards of at least 6 months) is sufficient to improve pregnancy outcomes.3
Question 5.
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Answer: C. It affects 30% to 40% of all neonates born with SLE.
The incidence of NLE is actually about 5% to 10%.4
1. Clowse ME, Jamison M, Myers E, James AH. A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol. 2008;199:127.e1-6.
2. Knight CL, Nelson-Piercy C. Management of systemic lupus erythematosus during pregnancy: challenges and solutions. Open Access Rheumatol. 2017;9:37-53.
3. Pearl E, Clowse ME. Systemic lupus erythematosus and pregnancy outcomes: an update and review of the literature. Curr Opin Rheumatol. 2014;26:118-123.
4. Teng YKO, Bredewold EOW, Rabelink TJ, et al. An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus. Rheumatology. 2018;57:1707-1720.