Which is safer? Celecoxib? Naproxen? Ibuprofen?

The long-awaited results from the PRECISION trial are in - with some caveats. Physicians have been awaiting these results since 2005 when the U.S. Food and Drug Administration called for a heart-safety clinical trial after a string of related drugs were pulled from the market. A small number of cardiovascular events suggested that celecoxib could lead to cardiovascular disease risk at high doses. The randomized, multi-center, double-blind, 10-year trial published in the New England Journal of Medicine on Nov. 13, shows that naproxen and ibuprofen at high doses are no safer than moderate doses of prescription-only celecoxib (Celebrex). In this slideshow, we summarize the results.

References:

Steven E. Nissen, M.D., et al. "Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis,"New England Journal of Medicine. Nov. 13, 2016. DOI: 10.1056/NEJMoa1611593