AAN Emphasizes Patient Perspective, Transparency in MS Guideline Development

Article

Lead author Alexander D. Rae-Grant, MD, explains the measures taken to ensure the panel got their 16-year multiple sclerosis recommendations update right.

The American Academy of Neurology (AAN) panel behind the implementation of 30 updated recommendations for multiple sclerosis (MS) disease-modifying therapy (DMT) from its most recent in 2002 did enough preliminary work to ensure there would be limited follow-up work.

In an interview with MD Magazine hours after the new recommendations were announced at the 70th annual AAN meeting in Los Angeles, lead author Alexander D. Rae-Grant, MD, of Cleveland Clinic in Cleveland, Ohio, and a Fellow of AAN, detailed the intricacies of designing comprehensive guidelines.

The panel that undertook the task followed guideline development recommendations from the Institute of Medicine, Rae-Grant said. They also hosted 2 series of public review, withheld panelists with any conflicts of interests to be involved in the systematic review process, actively sought out comment review from peers, and made what Rae-Grant believes to be an earnest effort to practice transparency on any conflicting opinions.

“The process was very robust, and allowed us to make, I think, the best recommendations we could do with the evidence available,” Rae-Grant said.

These new guidelines also benefitted from the input of patients with MS, as panelists with the condition helped lead rhetoric surrounding care issues from the very start, Rae-Grant said.

“All through this process they were kind of an important in what we did and what we delivered. I certainly want to emphasize that was very important — and a new thing,” Rae-Grant said.

The end result was a series of guidelines with limited instances of non-consensus recommendations and a reformed perspective on managing DMT care in a field with newer breakthrough therapies.

Click here to sign up for more MD Magazine content and updates.

For more extensive coverage pertaining to multiple sclerosis, check out MD Magazine's sister site, NeurologyLive. The Clinical Focus page serves as a resource for articles, videos, and newly released data from the field’s most attended conferences.

Related Coverage >>>

Rachelle Doody, MD, PhD: CREAD and GRADUATE trials for Alzheimer's

Teriflunomide Therapy Switch Improves Patient Satisfaction in Relapsing MS

Rick Rudick, MD: Progressing Collaborative, Evidence-Based MS Care

Related Videos
Mark Fendrick, MD | Credit: University of Michigan V-BID Center
Mark Fendrick, MD | Credit: University of Michigan V-BID Center
HCPLive Five at APA 2024 | Image Credit: HCPLive
© 2024 MJH Life Sciences

All rights reserved.