eAbstract: Autoantibodies against Bactericidal/Permeability-increasing Protein (BPI) in Children with Acute Pneumonia

December 11, 2009

Study authors aimed to determine whether serum and salivary anti-BPI autoantibodies also appear in the course of acute pneumonia in 24 otherwise healthy children.

Results from this study show that serum and salivary anti-BPI autoantibodies do not increase during the course of acute pneumonia.

Autoantibodies against Bactericidal/Permeability-increasing Protein (BPI) in Children with Acute Pneumonia

Journal: FEMS Immunology and Medical Microbiology (November 2009)

Authors: Steiner P, Otth M, Casaulta C, et al.

Purpose: To determine “whether serum and salivary anti-BPI autoantibodies also appear in the course of acute pneumonia in 24 otherwise healthy children.”

Results: “Nine (38%) and four (17%) patients had detectable serum anti-BPI immunoglobulin G (IgG) (> or =4 IU mL(-1)) and IgA (ratio> or =1.2), respectively, on the day of hospital admission (day 0). There was no increase in the rate of occurrence or the concentration of these antibodies in the convalescent sera obtained on day 30.”