eAbstract: Prevention and Treatment of Staphylococcus Aureus Pneumonia with a {beta}-Cyclodextrin Derivative

December 11, 2009

With regard to S. aureus pneumonia, these authors aimed to determine if beta-cyclodextrin derivatives were an effective treatment.

The IB201 derivative was discovered to be an effective treatment for S. aureus pneumonia, according to the researchers.

Prevention and Treatment of Staphylococcus Aureus Pneumonia with a {beta}-Cyclodextrin Derivative

Journal: Antimicrobial Agents and Chemotherapy

Purpose: To determine if beta-cyclodextrin derivatives are an effective treatment strategy for S. aureus pneumonia.

Results: “An examination of IB201 in murine S. aureus pneumonia demonstrated that the administration of this compound prevents and treats disease, protecting against mortality. Consistent with the vital importance of alpha-hemolysin in pneumonia caused by methicillin-sensitive and highly virulent methicillin-resistant S. aureus strains, IB201 protects against lethal challenge with both types of isolates.”