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Endo 2010 Abstract Roundup (Part 1)

Abstract #OR05-1The Metabolically Healthy Obese: A Prospective Study on Risk of Development of Cardiovascular Events

Authors: Verburg F, van Beek A, Sluiter W, et al.

Purpose: Because “there are no prospective data whether…metabolically healthy obese subjects are protected against cardiovascular disease,” the authors sought to establish some.

Results: “Metabolically health obeseity represents on lay a small subset of the total obese population. Metabolically healthy obese persons do not have an elevated cardiovascular risk when compared to normal eweight or overweight subjects with a similar metabolic profile.”

Abstract #P1-443Higher BMI and Dental Decay May Be LinkedAuthors: Bethlin K, Rafalson L, Creighton P, et al.

Purpose: The authors suspected that, because “obesity in youth has been a growing problem and dental caries remain the most common chronic disease of childhood…poor nutritional habits possibly link both of these conditions.”

Results: The prevalence of BMI>_ 85th percentile was 27.7% (n=18), more than 5% higher than the 2007-8 NHANES estimates (21.2%). Due to the fact that these children were fasting (8-12 hours), the prevalence of BMI>_85th percentile may be underestimated. The stress of induction may account for the impaired fasting BG observed in 7 subjects without elevated insulin levels. Daily caloric intake was abnormally high with intake exceeding 1200 calories in 71.4% of these children. Further analyses are needed to explore if juice and sweet consumption accounts for the excessive caloric intake and links higher BMI and dental decay.”

Abstract #P1-164Prevalence of Vitamin D Deficiency and Association with Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Retrospective Analysis

Authors: Kant R, Chandra R, Arzumanyan H, et al.

Purpose: “To estimate the prevalence of e25(OH)Vit D deficiency in type 2 diabetes mellitus and association of Vit D level with HbA1c.”

Results: “Our results showed high prevalence (91.1%) of Vit D deficiency in T2DM. Only 6.4% of patients were taking vit D when first seen at endocrine clinic despite regular primary care visits. Inverse relationship between serum Vit D level and glycemic control in our sample supports active role of Vit D in pathogenesis of T2DM. Finding of lower Vit D and higher HbA1c level in Black patients underscores the importance of aggressive screening and supplementation at this population. Since a majority of type 2 diabetic patients are diagnosed and treated by primary care providers, screening and vit D supplementation as part of routine primary care may improve health outcomes of this highly prevalent condition.”

Abstract #P2-522Inflammation Is Worse in Non-Hispanic Black Adolescents with Metabolic Syndrome than Non-Hispanic Whites or Mexican Americans: NHANES 1999-2006Authors: DeBoer M, Gurk M, Sumner A, et al

Purpose: “The value of inflammation in metabolic syndrome (MetS) in Non-Hispanic black adolescents is uncertain” and, accordingly, “no data is available on whether the association between inflammation and MetS is ethnic-specific.” The authors attempted to establish whether this association exists.

Results: “The percent of NHB, Non-Hispanic whites (NHW), and Mexican Americans (MA) with MetS was (4.3, 8.9, 9.6, P <0.01 for comparisons of NHW and MA with NHB). In all ethnic groups, hsCRP levels were higher in the presence of MetS than the absence. Among adolescents with MetS, jsCRP levels were twice as high in NHB adolescents as in NHW or MA. Furthermore, the difference in hsCRP levels in adolescents with and without MetS was twice as high in NHB as in NHW or MA. Overall, inflammation is more severe in NHB adolescents with MetS than NHW or MA adolescents with MetS. Consequently MetS could be an especially important indicator of inflammation in NHB adolescents.”

Abstract #P2-395Endocrine Disruptors and Polycistic Ovary Syndrome: Elevated Blood Levels of Bisphenol A in PCOS Women

Authors: Kandaraki E, Chazigeorgiou A, Palioura E, et al.

Purpose: The authors attempted to “determine BPA levels in serum of women with PCOS compared to controls, age, and body mass index matched, as well as the investigation of association between BPA levels and hormonal and metabolic parameters of studied subjects.”

Results: “BPA levels were significantly higher in lean…and obese PCOS women…compared to controls respectively. Additionally, significant higher insulin and androgen levels were found between PCOS and controls subgroups. A significant correlation was found between testosterone (r=0.188, p=0.03), 4-androstenedione (r=0.258, p=0.003) and BPA serum levels.”