Higher Spending Doesn't Mean Better Sepsis Survival Rates


Efforts to improve the value of sepsis care should be modeled after hospitals that achieve better results with fewer resources, say researchers.

Increased spending at high-cost hospitals does not appear to be associated with better short-term survival rates for patients with sepsis, according to a report in the February 28 issue of Archives of Internal Medicine.

Approximately 750,000 patients in the Unites States are affected by sepsis each year, according to the study’s authors, who believe that the condition is a perfect model for “examining the relationship between hospital spending and patient outcomes and for identifying potential opportunities to improve the value of hospital care.”

Tara Lagu, MD, MPH, of Baystate Medical Center in Springfield, MA, and Tufts University School of Medicine, Boston, and colleagues conducted a cross-sectional study of hospitals to determine whether higher levels of hospital spending were associated with better survival rates for patients with sepsis. Using the Perspective database, data were collected on 309 hospitals that cared for at least 100 patients with sepsis between June 1, 2004 and June 30, 2006.

Of the 166,900 patients observed, the average age was 70 years, 52% were women, and the majority (62%) were white. Most (84%) of the hospitals included in the study were located in urban areas, with half (49%) located in the southern United States.

Overall, 33,192 patients (20%) died while in the hospital. The median expected mortality rate for all hospitals was 19.2%. Of the hospitals with expected mortality between 18.5 and 19.5%, observed mortality rates ranged from 9.2 to 32.3%. Overall, 66 hospitals (21%) had a clinically and statistically significant higher-than-expected mortality rate. Twenty hospitals had observed mortality rates between 10% and 25% above the expected rate and 46 hospitals exceeded predicted mortality by 25%.

The median unadjusted hospital average cost per case was $18,256. More than one-third (34%) of hospitals exceeded expected costs by at least 10%, with a median excess cost per case of $5,207. When examining costs and mortality simultaneously, 22 hospitals (7%) had both significantly lower-than-expected costs and mortality rates, and 30 hospitals (10%) had both higher-than-expected costs and mortality rates.

The authors also identified a subset of institutions that provided high-value and lower-value care. Twenty-two hospitals (7%) had both significantly lower-than-expected costs and mortality rates, while 105 hospitals had higher-than-expected costs. These findings highlight potential opportunities to improve the value of sepsis care. For example, the 63,833 study patients treated at the 105 hospitals with higher than expected mean costs represent a potential $332 million dollars in excess hospital spending (using the median of $5,207 above expected costs).

"Hospital spending and adjusted mortality rates for patients with sepsis vary substantially, but higher hospital expenditures are not associated with better survival," the authors concluded. "Efforts to enhance the value of sepsis care could be modeled on hospitals that achieve lower-than-expected mortality and costs."

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