David M. Poppers, MD, PhD: A Promising New Esophageal Adenocarcinoma Tool


Direct optical endoscopy are often underutilized in screenings for EAC.

In a poster presented during the 2021 Digestive Disease Week (DDW) Virtual Meeting, researchers tested EsoCheck, a catheter/inflatable balloon-based device that allows for the rapid sampling of the mucosa in the distal esophagus.

Esophageal adenocarcinoma (EAC) has increased by about 6-fold in the last 40 years, with risk factors including long-standing gastroesophageal reflux disease (GERD).

Traditionally, the disease is screened for using direct optical endoscopy. However, this can be underutilized.

The new balloon technique does not require endoscopy or sedation but collects esophageal cells in about 3-5 minutes. The cells are analyzed through a proprietary molecular assay called EsoGuard for the presence of methylation above a defined threshold at specific sites of the vimentin and CCNA1 genes. There is a reported sensitivity and specificity of greater than 90% for the detection of nondysplastic/dysplastic Barrett’s esophagus and EAC.

The study included an unselected population of 99 patients over a wide age range, 90% of which completed the procedure.

In an interview with HCPLive®, David M. Poppers, MD, PhD, NYU Langone, explained the parameters of the initial study and why EsoCheck could help increase diagnoses of EAC.

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