Sheldon Sloan, MD: The Promise of Etrasimod at DDW


Arena Pharmaceuticals expects to move forward with later phase clinical trials testing etrasimod.

New early phase data shows etrasimod reduces certain immune cells and behaves as a selective immunomodulator rather than a broad immunosuppressive agent.

Research presented as a poster at the 2021 Digestive Disease Week (DDW) Virtual Meeting, a research team found the selective sphingosine 1-phsophate (S1P) receptor 1,4,5 modulator that reduces peripheral lymphocytes and impedes their recruitment to sites of inflammation, shows promise as a treatment for chronic immune-mediated inflammatory diseases.

The investigators tested the treatment in a phase 1, single-blind pharmacokinetic and pharmacodynamic study in 49 Japanese and Caucasian men.

Compared to placebo, 1 and 2 mg of etrasimod dosed daily for 7 days produced similar dose dependent reductions in absolute lymphocyte counts (ALC) in both subgroups of patients. The treatment resulted in total lymphocytes returning to at least 84% of baseline at day 15.

Etrasimod also reduced the mean percent change from baseline to day 7 in total T cells, total CD4+ and CD8+ T cells, naïve CD4+ and CD8+ T cells, central memory CD4+ and CD8+ T cells, effector memory CD4+ and CD8+ T cells, Th2 and Th17 cells, and total B cells and resulted in greater decreases in naïve and central memory T cells than in effector memory T cells.

In an interview with HCPLive®, Sheldon Sloan, MD, Vice President of Arena Pharmaceuticals, explained the promise of etrasimod and what the plans are for future studies.

Related Videos
Ana Maria Lopez, MD, MPH | Credit: Jefferson Health
Timothy Wilt, MD, MPH | Credit: ACP
HCPLive Five at ACC 2024 | Image Credit: HCPLive
Ankeet Bhatt, MD, MBA | Credit:
Ankeet Bhatt, MD, MBA | Credit:
Sara Saberi, MD | Credit: University of Michigan
Muthiah Vaduganathan, MD, MPH | Credit: Brigham and Women's Hospital
© 2024 MJH Life Sciences

All rights reserved.