Vitamin and Mineral Supplementation in Rheumatoid Arthritis: A Look at the Evidence


When are supplements warranted-and which ones are best supported by the evidence?

References1. Shea B, Swinden MV, Tanjong Ghogomu E, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Cochrane Database Syst Rev. 2013 May 31;(5):CD000951.2. Kostoglou-Athanassiou I, Athanassiou P, Lyraki A, et al. Vitamin D and rheumatoid arthritis. Ther Adv Endocrinol Metab. 2012;3:181-187.3. Haque UJ, Bathon JM, Giles JT. Association of vitamin D with cardiometabolic risk factors in rheumatoid arthritis. Arthritis Care Res. 2012;64:1497-1504.4. Johns Hopkins Arthritis Center. Suzuki Y, Wakabayashi T. Management of osteoporosis associated with rheumatoid arthritis and glucocorticoid-induced osteoporosis. Clin Calcium. 2015;25:1825-1834.6. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002;56:365-379.7. Lourdudoss C, Di Giuseppe D, Wolk A, et al. Dietary intake of polyunsaturated fatty acids and pain in spite of inflammatory control among methotrexate-treated early rheumatoid arthritis patients. Arthritis Care Res. 2018;70:205-212.8. Pattison DJ, Silman AJ, Goodson NJ, et al. Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study. Ann Rheum Dis. 2004;63:843-847.

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