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Chronic diuretic use and increased mortality and hospitalization in heart failureDiuretic use is associated with activation of neurohormones and disease progression in heart failure. Yet, diuretics are commonly prescribed, although little is known about their long-term effects. We performed a study based on propensity score matching, which indicated that in subjects with ambulatory, chronic, mild-to-moderate heart failure, diuretic use was associated with increased mortality and hospitalization. These findings call into question the wisdom of using long-term diuretic therapy in heart failure patients who are asymptomatic or minimally symptomatic.
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Creatine kinase-MB elevation following coronary artery bypass graft surgery: What is its significance and should it be measured in all patients?In their study consisting of coronary artery bypass graft (CABG) patients recruited from 4 major trials, Mahaffey found that creatine kinase-myocardial band (CK-MB) elevations following CABG surgery are independently associated with an increased risk of mortality in patients with non–ST-segment elevation acute coronary syndromes, especially if the peak CK-MB level is > 5 x the upper limit of normal (ULN).
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HIV in Prison: How Inmates and Partners Are at RiskPrisons are breeding grounds for STIs, including HIV. What can fix that?
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The EMR as a Catalyst for QualityThe EMR has long promised a brave new world in which clinical information is synthesized, individualized, and seamlessly delivered to the frontline clinician.
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The Logistics of Getting to HaitiIdentifying the needs of the Haitians who were affected by the earthquake, finding a place to stay and work, and getting there would be impossible for us without the help and coordinated efforts of many people.
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Atorvastatin pretreatment in early percutaneous coronary interventionAccording to results of the Atorvastatin for Reduction of Myocardial Damage During Angioplasty-Acute Coronary Syndromes (ARMYDA-ACS) trial, short-term pretreatment with high-dose atorvastatin prior to percutaneous coronary intervention improves clinical outcome in subjects with unstable angina and non-ST-segment elevation myocardial infarction. These findings support the upstream administration of high-dose statins in subjects with acute coronary syndrome treated with an early invasive strategy.
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Are Hillary Clinton and Donald Trump Healthy Enough to be President?Will our next president be medically fit? And how much is the public entitled to know about candidates’ personal health?
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FDA Approves Adamis' Cheaper Alternative to EpiPenAdamis developed a single-dose epinephrine pre-filled syringe to treat anaphylaxis.
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Updates in Surgery: Percutaneous Coronary Intervention, Perioperative Biomarkers, and TroponinDuring a follow-on session at the 2013 Southern Hospital Medicine Conference, Steven Cohn, MD, discussed the effect of PCI on subsequent non-cardiac surgery outcomes, monitoring specific hormone levels as indicators of cardiovascular risk, and other hot topics in perioperative medicine.
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Outcomes in women vs men with heart failure and preserved ejection fractionThe epidemiologic finding that women with heart failure have better overall survival than men may be because of the higher prevalence of diastolic heart failure or heart failure with preserved ejection fraction (HF-PEF) among women.
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Melanoma: Improving Clinical Outcomes Through Advances in Immunotherapeutics and Targeted TherapyMetastatic melanoma has limited treatment options, but advances in the understanding of the oncogenic mutations that drive this cancer and how the immune system can be better modulated to fight melanoma provide a new generation of active approaches for patients.
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Thoracic and abdominal aorticatherosclerosisIt was not until Virchow identified the cellular contributions to thrombosis that physicians began to visualize arteries as dynamic tissues.
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A Tour of Hospital Medicine in the BlogosphereWith the ranks of hospitalists already over 20,000 strong and growing every day, hospital medicine is the fastest-growing medical specialty in the history of American healthcare
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Uncovering masked hypertension: Is the blood pressure really normal?A number of studies have documented the incremental predictive ability of 24 hour ambulatory blood pressure (BP) monitoring over traditional office or casual BP monitoring for predicting adverse cardiovascular events.
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A Sense of Urgency in Sanfilippo Therapy DevelopmentWith no real standard-of-care for Sanfilippo syndrome patients, Brian Bigger, Ph.D., discusses the sense of urgency he and his colleagues feel while researching.
