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Recent Trends in Medical Simulation, with Implications for Open-Source SoftwareMedical simulation applies a numerical algorithm that synthesizes a clinical effect on a digital representation of patient anatomy.
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Early statin therapy in acute coronary syndromePatients who survive an acute coronary syndrome are at much higher risk of a recurrent event within the following month than patients with stable coronary syndromes. Statin therapy lowers the risk of recurrent events for many years but also reduces the risk of another event within the weeks to months following the initial acute coronary syndrome. The mechanisms that contribute to this benefit are likely related to improved endothelial function, decreased vascular inflammation, and reduced prothrombotic factors. Observation studies show an early reduction in mortality with statin therapy started before discharge from the hospital after an acute coronary syndrome.
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Does Anger Predict a Higher Likelihood of Cardiovascular Events?This meta-analysis attempts to definitively answer questions about the role of anger in cardiovascular events.
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Treatment Strategies in Hepatitis CThe most important treatment outcome in hepatitis C is sustained virological response, due to its impact on reducing the risks of liver-related mortality, hepatocellular carcinoma, and hepatic decompensation. The degree of baseline liver disease, IL28B genotype, and HCV genotype are important determinants of response to treatment.
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Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.
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Early Initiation of Rivipansel for VOC in Sickle Cell DiseaseEarly initiation reduces hospital stays and length of IV opioid use.
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MI and Ischemic Heart Disease in Overweight and ObesityA review of the relationship between body mass index, metabolic syndrome, and cardiovascular disease and all-cause mortality.
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Long-term Effects of Post-transplant Respiratory Viral InfectionsData suggest respiratory infections in transplant patients are associated with increased long-term mortality and morbidity.
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Improved retinopathy in a patient with type 1 diabetes: A review of the role for HMG-CoA reductase inhibitors in the treatment of diabetic retinopathyA 36-year-old Hispanic man was diagnosed with type 1 diabetes in 1987 and dyslipidemia in 2001.
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More Intensive Blood Pressure Goals Reserved for Most Severe Kidney Disease: KDIGORecent updates by the 8th Joint National Committee (JNC 8), the American and International Societies of Hypertension (ASH-ISH), and KDIGO recommend target blood pressure of less than 140/90 mm Hg for most individuals, including those with CKD.
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5-FU Dose Optimization: Another Step Towards Personalizing Cancer CareAccording to the Centers for Disease Control and Prevention, colorectal cancer is the second leading cancer killer in the United States, affecting both men and women.
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Another Study Shows No Malignancy after BiologicsRheumatoid arthritis patients who have had a malignancy and are receiving a TNFi or rituximab (RTX), do not appear to have an increased risk of cancer recurrence.
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Association between stroke risk and body mass index in womenThe study by Kurth and Buring consisted of a prospective analysis among nearly 40 000 women participating in the Women's Health Study.
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Anomalous origin of the right coronary artery in an asymptomatic athlete: What if he did not have a murmur?Sudden death in young athletes is shocking because it is unexpected in these seemingly healthy individuals. We present the case of an athlete who was found to have an incidental murmur during a screening physical, which led to a diagnosis of an anomalous origin of the right coronary artery with an intramural course. This congenital anomaly has been well recognized to result in sudden death; thus, it was fortunate that the condition was identified in our patient. We provide a brief overview of the literature, discuss the challenges faced in diagnosing such coronary abnormalities, and review the various management options that are available.
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Higher All-Cause Mortality Associated with Hyponatremia in Chronic Kidney DiseaseStudy results show hyponatremia is closely associated with all-cause mortality in patients with chronic kidney disease (CKD), but few previous studies have examined this relationship.
