J. Roberto Duran III, MD


Aspirin Therapy for Prevention of Cardiovascular Disease in Patients with Diabetes

Coronary artery disease is the leading cause of death in patients with diabetes. Platelets play a major role in the pathophysiology and clinical manifestations of ischemic heart disease. It is well known that platelets in diabetic patients are hyperreactive, with exaggerated adhesion, aggregation, and thrombin generation. Aspirin and other antiplatelet agents have been shown to reduce the incidence of ischemic events in patients with and without diabetes, whether or not they have a history of cardiovascular disease. This article reviews the latest recommendations for the use of antiplatelet therapy in the primary and secondary prevention of cardiovascular events in diabetic patients.

Peter Zimetbaum, MD1: From the 1Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA


Amiodarone use and permanent pacing for atrial fibrillation: Are there differences between the sexes?

Among patients with atrial fibrillation, amiodarone (Cordarone, Pacerone) is the most useful drug for the preservation of sinus rhythm.1-3 Although amiodarone carries a well-known risk of potentially serious noncardiac toxicities, perhaps less well recognized is its major cardiovascular side effect of bradycardia.

Healthy Body Healthy Mind


Hyponatremia: A Serious Sodium Deficiency

Dr. Verbalis, Dr. Green, and Dr. Miller explain the effects of hyponatremia and Marilyn Getty describes her experience with the condition.

Nico R. A. Mollet, MD


High-resolution spiral computed tomography coronary angiography

We evaluated the performance of the 64-slice spiral computed tomography coronary angiography scanner in 52 symptomatic patients with stable sinus rhythm and found that it was highly reliable in ruling out the presence of a significant coronary stenosis. This technique may be regarded as a suitable alternative to invasive coronary angiography.

Jeffrey W. Stevens MD, PhD


Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?

The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.

John Lynn


Does Your EHR Consultant Have Your Best Interests in Mind?

When selecting an EHR for your practice, using an EHR consultant can save you time, money, and headaches.

Sharon Packer, MD


Thor: From Myth to Marvel Comics to Movies to Medical Commentary

How the movie Thor impacts the changing public image of physicians.

Robert J. Mintz, Esq.


Covering Your Assets: Tailoring Your Asset Protection Plan to Your Career Stage

The type of asset protection planning you need depends on where you are in your career.

Timo E. Strandberg, MD, PhD


Low cholesterol level in midlife and quality of life in old age

We found that lower cholesterol levels in middle age predicted lower total mortality and better physical quality of life in old age after 39 years of follow-up. No difference was seen in the mental component of quality of life. These findings support current guidelines for cholesterol goals and show that a low risk-factor level in midlife can affect long-term mortality and morbidity, postpone physical disability, and improve quality of life in old age.

ClinkShrink from Shrink Rap


Genetic Friendships

A review of recent research into the genetics found in social networks.

Alan Berkenwald


I Before We, When Before Thee

Graduating medical school, "we" all stood and repeated, deep within our private solemnity, a modern version of the Hippocratic oath. Nowhere is a "we" to be seen. Instead, "I swear... I will keep... I will impart... I will follow..." transitions us from students to practitioners.

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