Single-agent pixantrone, an investigational agent, showed encouraging third-line responses, duration of responses, and progression-free survival (PFS) compared with other single-agent chemotherapies in patients with relapsed aggressive non-Hodgkin lymphoma (NHL) in the phase III, randomized, open-label, multicenter EXTEND trial. In the study, patients with relapsed/refractory NHL treated with pixantrone achieved significant increases in complete response (CR) and overall response (ORR) and demonstrated a positive trend in overall survival (OS) compared with other chemotherapy agents, according to Ruth Pettengell, MD, of St. Georges Hospital in London, who presented these results at a poster session. “An anthracycline with reduced cardiotoxicity that can be used for salvage therapy of aggressive NHL meets a significant unmet medical need,” she said.