HER2-positive breast cancer has long been recognized as an aggressive disease, but women with small node-negative tumors are considered low risk for recurrence and do not always receive adjuvant therapy. Data presented by Heather L. McArthur, MD, MPH, Memorial Sloan-Kettering Cancer Center in New York, and colleagues in a poster session at this week’s Breast Cancer Symposium in San Francisco suggests perhaps they should. In comparing outcomes between women who received adjuvant trastuzumab for low-risk HER2-positive tumors and those treated before trastuzumab was available, they concluded adjuvant trastuzumab (Herceptin) reduces recurrence rates and mortality.