Fatty acid synthase (FAS) is a lipogenic multienzyme that catalyzes the final step in de novo fatty acid synthesis. Recently, FAS has been characterized as an oncogene and is overexpressed in various tumor types including prostate. FAS expression does not appear to be regulated by nutritional controls. However, when omega-3 fatty acid (w-3 FA) and docosahexanoic acid (DHA) are added, FAS expression appears to be inhibited.
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