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Spotlight -

This Year In Medicine 2025

Opinion|Videos|July 22, 2024

Head-to-head Study of Upadacitnib and Dupilumab in Atopic Dermatitis (Level Up)

Author(s)Christopher G. Bunick, MD, PhD

An atopic dermatitis expert describes the results of the Level Up study, a phase 3b/4 trial comparing upadacitinib and dupilumab, which were recently presented at RAD 2024, focusing on the primary and secondary outcomes of the study.

Episodes in this series

1 KOL is featured in this series.

EP. 1 Systemic Treatments in Atopic Dermatitis: Use and Treatment Inertia

1 KOL is featured in this series.

EP. 2 Atopic dermatitis Clinical Trial Endpoints

1 KOL is featured in this series.

EP. 3 Treatment and Patient Reported Outcomes in Atopic Dermatitis

1 KOL is featured in this series.

EP. 4 Head-to-head Study of Upadacitnib and Dupilumab in Atopic Dermatitis (Level Up)

1 KOL is featured in this series.

EP. 5 Ongoing Studies in Atopic Dermatitis and Recommendations for Clinicians

Head-to-head studies of systemic treatments and studies evaluating sequencing of systemic treatments are rare. Results of one such study, Level Up, were recently presented at RAD 2024. Can you describe the study briefly and discuss primary and secondary outcomes in phase 3b/4 study that compared upadacitnib and dupilumab (Level Up, RAD 2024)?
What are implications of these results in everyday practice?

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