Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases

Journal: Clinical Cancer Research (December 2009)

Authors: Amaravadi RK, Schuchter LM, McDermott DF, et al.

Purpose: To assess the combination of the oral alkylating agent temozolomide and the oral multikinase inhibitor sorafenib in patients with advanced melanoma.

Results: Temozolomide plus sorafenib was found to be well tolerated and showed activity in patients with melanoma who had no previous history of temozolomide treatment. The authors conclude that the temozolomide and sorafenib combination warrants further investigation in patients with advanced melanoma.

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