Internal Medicine

Study shows gluten alters bowel functions in patients with IBS-D and that removal of gluten from the diet may reduce the frequency of bowel movements.

Recognizing that melatonin secretion from the gastrointestinal (GI) tract improves abdominal pain in irritable bowel syndrome (IBS) but decreases with age, Polish researchers from the Medical University of Lodz aimed to define the effect of administering melatonin in postmenopausal women with different predominating IBS symptoms.

Results of a pair of phase 3 placebo-controlled clinical studies conducted by a worldwide team of researchers have deemed Merck's Isentress (raltegravir) antiretroviral treatment safe, tolerable, and effective in multidrug-resistant HIV patients who are naïve to integrase inhibitors.

By adopting a comprehensive set of case management policies for the care of diabetic and hyperglycemic patients, Johns Hopkins Hospital improved in-hospital mortality rate, reduced length of stay, and reduced hyperglycemia.

Exposure to insulin glargine and metformin did not cause increased risk of cancer or worse cancer outcomes.

Results of a three-year trial of the experimental GLP-1 receptor agonist albiglutide showed that it had a better effect on HbA1c, fasting blood glucose, and body weight than two comparator drugs.

Prescription-strength doses of vitamin D improve highly prevalent comorbidities among diabetic women, such as depression and pain, and also improve risk factors such as excess weight and high blood pressure.

The US Food and Drug Administration has awarded "breakthrough therapy" status to a synthetic copy of a naturally occurring human hormone for the treatment of acute heart failure (AHF), drug developer Novartis announced today.

The chronic constipation associated with conditions such as IBS can lead to serious health complications if left untreated.

Nearly two years after Eli Lilly and Co. halted a pair of clinical trials on its gamma-secretase inhibitor for Alzheimer's disease following the candidate's failure to demonstrate results superior to placebo, the drug maker has terminated a phase 2 study of its investigational beta-secretase (BACE) inhibitor for the same neurological condition - this time citing liver abnormalities.

Hypertriglyceridemia combined with insulin resistance may lead to increased platelet activation in women with polycystic ovary syndrome (PCOS).

Insulin sensitivity improved after three nights of adequate sleep in nondiabetic men after days of inadequate sleep.

Initial data show similar efficacy but different costs among injectable insulin treatments for patients who fail oral antidiabetic drugs.

A recent study suggests that skipping breakfast in overweight women may lead to insulin resistance.

Researchers recommended long-term surveillance of patients with hyponatremia on discharge.

Dr. Lim discusses the challenges of diagnosing and treating lupus, the tools and resources offered by the Lupus Initiative, and the impact of unconscious bias on care.

Merck & Co. has ceased development of its experimental therapy for Parkinson's disease after the drug failed to show superiority to placebo in initial data from a series of phase III clinical trials.

A high-potency probiotic supplement that mimics the effect of morphine in the gut may reduce the development of visceral pain in irritable bowel syndrome (IBS).

Approved by the US FDA in August 2012, Gilead's Stribild is indicated to treat human immunodeficiency virus type 1 (HIV-1) infection in adults who have no prior experience with antiretroviral therapy.

Results of a recent clinical trial by researchers at the Department of Rehabilitation Medicine in the Affiliated Tenth People's Hospital of Tongji University, in Shanghai, China, have deemed locally injected methylcobalamin more effective than its orally administered counterpart as a treatment for subacute herpetic neuralgia.

As irritable bowel syndrome (IBS) remains a complicated condition to treat with an etiology that's still unknown, it's difficult for physicians to find the best proven therapies among new remedies and the variety of pharmacological and nondrug options they have been trying for years.

While it's already clinically understood that most patients with Crohn's disease suffer a recurrence following an intestinal resection, researchers have not evaluated the best strategy to prevent the disease from recurring.

Patients taking linaclotide experience clinically meaningful improvement in abdominal and bowel symptoms, which closely correlate with the US Food and Drug Administration's new criteria for irritable bowel syndrome with constipation (IBS-C).

Esophageal pH monitoring is more cost effective than the long-term use of proton-pump inhibitors (PPIs), since it can help rule out gastroesophageal reflux diseases (GERD) and avoid the unneeded costs associated with prolonged medication therapy.

While it's important for nutrition and an integral part of patients' lives, food also plays a role in functional gastrointestinal disorders such as irritable bowel syndrome (IBS).

Andrew J. Muir, MD, MHS, said having more antiviral hepatitis C drugs in the pipeline could spur more people to accept treatment and improve patient outcomes.

Presenters at Digestive Disease Week 2013, held May 18-21, 2013, in Orlando, Fla., differed on the risks of surgical complications from the use of biologic agents.

The American College of Rheumatology recently announced a new easy-to-use curriculum and tools aimed to help medical professionals advance the diagnosis, treatment, and management of lupus.

The US Food and Drug Administration (FDA) today expanded approval of Simponi (golimumab) to treat moderate to severe ulcerative colitis, a chronic inflammatory bowel disease (IBD) that affects some 620,000 Americans.

Study supports the current practice of post-surgery H. pylori eradication in patients with perforated peptic ulcers.