Schizophrenia

Patients treated with LAIAs had a lower risk of hospitalization for any cause, hospitalizations for psychiatric disorders, hospitalizations for schizophrenia, and incident suicide attempts compared to patients treated with oral antipsychotics.

Investigators confirmed olanzapine and samidorphan (LYBALVI) resulted in statistically significant less weight gain compared to patients with schizophrenia between 16-39 years treated with olanzapine.

Lois Choi-Kain, MD, MEd, discusses her field's interest in improving the modern diagnosis and evidenced-based treatment of personality disorders.

A 6-year mirror analysis of risperidone, once-monthly paliperidone palmitate or once-monthly aripiprazole concludes suggesting the regimens may serve as an alternative to clozapine.

The treatment represents the only FDA approved orally dissolving sublingual film for this patient population.

Clinical decision support intervention resulted in a rate of change in total modifiable CV risk that was 4% lower among intervention patients compared to control.

Melatonin is seen as the most promising treatment in this patient population.

The treatment met the pre-specified primary endpoint of significantly less weight gain in the ENLIGHTEN-Early trial.

There was an elevated risk of violence perpetration in both men and women with schizophrenia spectrum disorder.

Ineligible patients with schizophrenia have a higher risk of hospitalization for a number of reasons, including suicide attempts.

Brexipiprazole has been previously approved for adults with schizophrenia and adults with major depressive disorder.

Between 20-30% of patients with schizophrenia do not respond to the first-line antipsychotic treatment.

Six-month paliperidone palmitate is the only twice-yearly injectable treatment for patients with schizophrenia.

There are a number of ongoing clinical trials testing psychedelics as a treatment for psychiatric disorders.

There was little difference in hospitalization and mortality rates between vaccinated schizophrenia patients and vaccinated control patients.

Schizophrenia PRS was linked to increased disorganized symptom dimension scores.

Severe mental disorders had the highest odds ratios for the risk of mortality.

On this episode of Coping After COVID, Dr. Craig Chepke discusses the challenges for schizophrenia patients.

The oral combination therapy can also be used as acute treatment for manic or mixed episodes.