Asthmatics with Elevated Eosinophil Levels Far More Likely to Require Hospital Admission
January 13th 2017A retrospective cohort analysis showed patients with severe asthma and elevated eosinophil levels accounted for only 3% of all asthma patients but an estimated $1.3 billion in costs due to hospital admission for asthma exacerbation.
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Recent Trial: Ranibizumab Did Not Prevent New Macular Atrophy in Cases of Neovascular AMD
January 10th 2017Whether injected monthly or according to a TREX regimen, ranibizumab did not have a statistically significant effect on the development of new macular atrophy in eyes with neovascular AMD.
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Tubulointerstitial Nephritis and Uveitis Syndrome Threatens Vision in Some Patients
December 28th 2016Some cases of tubulointerstitial nephritis and uveitis syndrome, or TINU, have a poor visual prognosis, so early diagnosis and treatment are recommended. Diagnosis requires detailed history taking, whole-body imaging studies, and examination of renal function.
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Study Disputes Anti-VEGF Injection Link to Long-Term Intraocular Pressure Increase
December 22nd 2016During follow-up periods ranging from six months to 10 years, no increase in IOP over time was found in AMD or DME patients who received intravitreal injection of an anti-VEGF agent, no matter how many injections they received.
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Sirolimus Showed Improvements in Patients with Active Noninfectious Posterior Uveitis
December 21st 2016In the SAKURA study, a greater proportion of those in the intravitreal sirolimus treatment groups than those in the active control group met the primary endpoint, a vitreous haze score of zero at Month 5 without the use of rescue therapy.
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Studies Conflict on Ranibizumab's Stroke Risk
December 21st 2016In a new study, stroke occurred in 6.6% of the ranibizumab-treated group, compared with 7.0% of the controls matched by sociodemographic factors and comorbidities and 6.7% of the controls matched by sociodemographic factors only. These differences were not statistically significant.
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For Bilateral Uveitic Glaucoma, It May be Best to Operate on Second Eye Sooner than Later
December 20th 2016A retrospective review of patients with bilateral uveitic glaucoma who had filtration surgery in both eyes at different times found that the second surgically treated eye showed greater glaucomatous disc progression than the first.
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Antibody Development an Obstacle in Treating Uveitis with Humira
December 19th 2016A Spanish research team found an association between testing positive for antibodies to adalimumab (Humira) and a worse outcome of uveitis, but only in those who tested positive permanently. They also found that this association correlated with undetectable trough levels of Humira.
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Skin Test Can Predict Remissions in Urticaria
December 9th 2016Chronic idiopathic urticaria (CIU) typically lasts one to five years. Nevertheless, in 14% of CIU patients, the disease lasts longer than five years, and few predictors of its remission rate are available. However, a pair of Thai investigators recently showed that the results of two simple skin tests could predict two-year remission rates in patients with CIU.
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Diabetic Macular Edema Study: Ozurdex Outperformed Avastin, but Not Without Drawbacks
November 29th 2016Monthly Avastin injections and quarterly Ozurdex injections produced equivalent improvements in best-corrected visual acuity after 7 months. However, Ozurdex reduced central subfield thickness nine times more than Avastin did, though it was associated with elevated intraocular pressure.
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Estimating the Prevalence of Noninfectious Uveitis with a Massive Claims Database
November 4th 2016The prevalence of noninfectious uveitis was 121 cases per 100,000 adults and 29 cases per 100,000 children. By such estimates, nearly 300,000 adults and 22,000 children in the United States had the disease in 2015.
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