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Medication nonadherence and adverse outcomes in CAD patientsNonadherence to beta blockers, statins, or angiotensin-converting enzyme inhibitors is common (21%-29%) among patients with coronary artery disease (CAD). Patients who do not adhere to their medication regimens are at increased risk of mortality, cardiovascular hospitalizations, and revascularization procedures; thus, medication nonadherence should be a target for quality improvement interventions to maximize the outcomes of CAD patients.
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Predicting survival in elderly patients with heart failureOver a period of 14 years, we followed 282 patients aged 70 years or older who were hospitalized with heart failure. Median survival was 2.5 years, but 25% of patients died within 1 year, and 25% survived for at least 5 years following hospital discharge. A simple 7-item risk score based on data readily available at the time of hospitalization effectively stratified patients into low-, intermediate-, and high-risk categories for subsequent mortality.
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MI and Ischemic Heart Disease in Overweight and ObesityA review of the relationship between body mass index, metabolic syndrome, and cardiovascular disease and all-cause mortality.
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Tardive Dyskinesia: Clues to the Diagnosis and TreatmentTardive dyskinesia is a common problem associated with the long-term use of potent antipsychotic drugs. It has become less common with the increased use of the newer atypical antipsychotic medications. The condition is manifested by abnormal orofacial, extremity, and sometimes trunk movements. Decades after it was first identified, our understanding of the pathophysiology of tardive dyskinesia remains incomplete, and currently no definitive treatment is available. Encouraging advances in recent years point to promising new treatment options. This article discusses factors that may predispose to tardive dyskinesia as well as the latest developments in treatment.
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Incidence of death and MI associated with stopping clopidogrel after ACSRates of death and myocardial infarction were assessed for a national sample of acute coronary syndrome patients after stopping clopidogrel. In the first 90 days after stopping treatment, patients experienced a nearly twofold increased risk of adverse events compared with subsequent follow-up intervals for patients treated medically without stents and for patients treated with coronary stents. This suggests a possible clopidogrel rebound effect, but additional studies are needed to support this hypothesis and to identify strategies to reduce early events after clopidogrel cessation.
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Hedgehog Signal Inhibition Hope or Hype?Once a human malignancy metastasizes, currently available cytotoxic chemotherapy is usually palliative. While conventional chemotherapy regimens are associated with objective tumor regression, this only occurs in a minority of patients.
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The clinical ramifications of CIBIS III: Does the sequence of medication initiation really matter?The development of new and innovative mechanical and pharmacologic therapies for the broad spectrum of cardiovascular disease has led to dramatic changes in the makeup of clinical practice.
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The Impact of Pollution on The SkinA Lenox Hill Hospital dermatologist outlines the threats surrounding, and ideal therapies for, dermatological conditions brought on by pollution.
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The Real Risks of SittingThis study was a meta-analysis that examined the association between sedentary behavior and hospitalizations, all-cause mortality, cardiovascular disease, diabetes and cancer in adults.
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Chronic Leg Ulcer in a Middle-Aged ManA 60-year-old gentleman presented to a clinic with a large ulceration over his left tibia. The wound was friable, erythematous, and purulent, with necrotic involvement of the tibial tendon sheath. He reports that the lesion started 15 years ago and worsened after surgical debridement 10 years ago. High-dose prednisone helped in the past, but other medications have been of no help. Recently, the patient developed intense pain with occasional fevers, chills, and night sweats. He has type 2 diabetes mellitus, but denies any history of bowel difficulties, hepatitis, or arthralgias. What is your diagnosis?
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White-coat hypertension and the development of sustained hypertensionFor 50 years, hypertension has been recognized as the most significant risk factor for the development of symptomatic cardiovascular disease in Western society.
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The Third Annual Gearhead's Holiday Gadget-Buying GuideA brief guide to the must-have gadgets for you and your loved ones this holiday season.
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If Healthcare Reform FailsWhile the changes President Obama and Democratic leaders in Congress are proposing are considerable (they could reduce the deficit within two decades), they aren't a government takeover.
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How Should I manage This Young Woman's Painful Genital UlcersA 29-year-old female accountant is seen by you for painful lesions in the vulva. Her past medical history is notable only for the use of the hormonal contraceptive patch. She has been married for one year and denies a past history of herpes. Examination reveals two mildly tender grouped ulcerative lesions on the left labia.
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Head and Neck Cancer Vaccines Get Orphan StatusEarlier this year, the FDA granted Orphan status to 2 vaccines designed to fight head and neck cancers. Find out how they work and trials in progress.
