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Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular EventsThe Multi-Ethnic Study of Atherosclerosis study examined the association of coronary artery calcium volume and density with incident cardiovascular events.
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Stress echocardiography in diabetes mellitusCardiovascular disease is a leading cause of death for persons with diabetes, accounting for almost 80% of mortality in this group in the United States.
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Are statins cardioprotective in patients undergoing major vascular surgery?We evaluated the cardioprotective effects of intensive statin therapy before major vascular surgery in a prospective study of 359 subjects. After multivariate analysis, lower low-density lipoprotein (LDL) cholesterol was associated with decreased myocardial ischemia, troponin T release, and 30-day and late cardiac events. Furthermore, higher doses of statins were associated with better cardiac outcome, even after adjusting for LDL cholesterol.
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Prediction of coronary artery disease in patients with diabetes and albuminuriaWe developed a set of equations to predict the risk or probability of developing coronary artery disease (CAD) in 10 years among American Indians. The equations are based on the significant risk factors identified in the Strong Heart Study, a longitudinal study of cardiovascular disease in American Indians. The equations can be used in patient education and to evaluate the efficacy of CAD prevention and intervention programs.
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Contemporary cardiac imaging in hypertrophic obstructive cardiomyopathyFeatures of hypertrophic obstructive cardiomyopathy (HOCM) include obstruction at the left ventricular outflow tract (caused by a markedly thickened proximal interventricular septum) and systolic anterior motion of the mitral valve. The case discussed here illustrates several classic features of this disease including clinical presentation, diagnostic workup, and noninvasive and invasive management.
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Keeping an Eye on Hepatitis C Virus Drug ApprovalsWith the recent approval of new hepatitis C treatments, payers are increasingly concerned with controlling costs in this category through policies that may affect treatment decisions.
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Multivessel CAD in ACS patients: Four important implicationsThe article by Schwartzman and Brener (page 33) has 4 important implications for the treatment of acute coronary syndrome (ACS) patients who are found to have multivessel coronary artery disease (CAD) during diagnostic coronary angiography.
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Analysis of regional left ventricular functionWe performed cineventriculography, unenhanced echocardiography, contrast-enhanced echocardiography, and magnetic resonance imaging to define the presence of regional left ventricular wall motion abnormalities. Interobserver agreement in the analysis of regional wall motion abnormality was highest for contrast-enhanced echocardiography, followed by cineventriculography and cardiac magnetic resonance imaging; it was lowest for unenhanced echocardiography. Contrast-enhanced echocardiography also showed the highest accuracy in the detection of panel-defined regional wall motion abnormalities.
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Mestinon and Other Ways to Treat Myasthenia GravisIn this video, Beth Stein, M.D., and myasthenia gravis patient Anaya Mitchell discuss mestinon, steroids, and other treatment methods for myasthenia gravis.
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Exercise capacity and cardiovascular risk: Study provides clinicians with important insightsA study by Peterson and colleagues used a large electronic patient database to demonstrate how patients at risk for nonfatal coronary events may be identified using reduced exercise capacity on treadmill stress testing as a parameter.
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BRAF Mutation Emerging as Prognostic in KRAS Wild-Type mCRC PatientsIn metastatic colorectal cancer (mCRC), mutations in the BRAF gene are emerging as prognostic indicators of worse outcomes.
