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BRAF Mutation Emerging as Prognostic in KRAS Wild-Type mCRC PatientsIn metastatic colorectal cancer (mCRC), mutations in the BRAF gene are emerging as prognostic indicators of worse outcomes.
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Intra-Arterial Treatment for Acute Ischemic StrokeThe primary objectives of treating acute ischemic stroke are to prevent death and limit functional disability. Similar to acute myocardial infarction (AMI), timely reperfusion using systemic thrombolysis has been shown to improve outcome of acute stroke, namely functional neurologic recovery, but not mortality. But unlike AMI, the role of intra-arterial or endovascular therapy in acute stroke has not been clearly established.
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Leveraging Telemedicine During the COVID-19 OutbreakTelemedicine platforms can be used to monitor symptoms remotely and reduce overcrowding in healthcare facilities.
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Does low on-treatment diastolic blood pressure influence prognosis in systolic hypertension patients?From the Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium.
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FDA Says Simvastatin & Ezetimibe Unlikely to Cause CancerThe FDA concludes that the cholesterol-lowering drugs simvastatin (Zocor),ezetimibe (Zetia), and Vytorin (ezetimibe/simvastatin) are not likely to increase cancer risk.
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Upper Chest Wall Lesion in a Middle-aged WomanA 58-year-old woman presented to clinic with concerns about this skin lesion on her upper chest. She reports it has been present for 1 year and is slowly enlarging. The lesion is otherwise asymptomatic and her past history is only significant for rheumatoid arthritis (RA), for which she takes methotrexate and etanercept.
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How the Law Should Handle the Opioid EpidemicWhile the opioid epidemic has had a devastating impact on American families, there is some hope that the future is bright.
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Noncardiovascular Effects Associated with StatinsThis review presents up-to-date evidence regarding the noncardiovascular effects associated with statins, both adverse and beneficial.
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How Should I Handle This Patient Who Leaks Urine?A 58 year old G2P2, married woman presents to your office for her annual well woman exam. Upon questioning, she tells you that for several months she's been having trouble with urinary leaking. "I just can't seem to get to the bathroom on time and I feel like I go more often than usual." She also has been urinating at least twice during the night. She denies urinary burning or dysuria
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Physicians Unite on Twitter, Divide on PracticeThe physician community on Twitter is a vibrant, diverse one. But the platform's use in and out of the clinic is still subject to debate.
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Amiodarone use and permanent pacing for atrial fibrillation: Are there differences between the sexes?Among patients with atrial fibrillation, amiodarone (Cordarone, Pacerone) is the most useful drug for the preservation of sinus rhythm.1-3 Although amiodarone carries a well-known risk of potentially serious noncardiac toxicities, perhaps less well recognized is its major cardiovascular side effect of bradycardia.
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Noninvasive assessment of coronary artery bypass grafts with 64-slice computed tomographic angiographyWe evaluated the accuracy of the 64-slice computed tomography (CT) angiography scanner in subjects who were scheduled to undergo invasive angiography for possible stenosis in coronary artery bypass grafts. Results showed that the improved resolution of CT scanners with 64-slice technology allowed for a precise delineation of bypass graft occlusion or stenosis. It permitted an accurate noninvasive assessment of bypass grafts, even in subgroups of subjects with suboptimal scan conditions, such as those with arrhythmias or higher heart rates.
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AHA 2010: New Anti-clotting Drug Offers Alternative to WarfarinRivaroxaban is as effective as warfarin in preventing blood clots and stroke and does not increase bleeding risk in patients with atrial fibrillation.
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2011 ACC: Shorter Duration of Antiplatelet Therapy for Select PatientsHow long should a patient take an antiplatelet drug to reduce clotting following a stent procedure?
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Are HDL cholesterol levels clinically significant in patients with low LDL cholesterol levels?There is some debate about whether the risk of cardiovascular events associated with low high-density lipoprotein (HDL) cholesterol levels is attenuated by very low low-density lipoprotein (LDL) cholesterol levels (< 60 mg/dL), which can be obtained with statins and combination therapy.
