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New Device Uses Submarine Technology to Diagnose Stroke Quickly

A device that uses submarine technology is a new paradigm for the detection, diagnosis, and monitoring of stroke.

A medical device developed by retired US Navy sonar experts that uses submarine technology is a new paradigm for the detection, diagnosis, and monitoring of stroke. Each type of stroke and brain trauma is detected, identified, and located using a simple headset and portable laptop-based console, according to a team of interventional radiologists at the Society of Interventional Radiology’s 36th Annual Scientific Meeting in Chicago.

The device’s portability and speed of initial diagnosis (under a few minutes) make it appropriate for many uses outside of the hospital setting, including by military doctors in theater who need to assess situations quickly and efficiently in order to provide critically injured troops with treatment.

“We have developed and validated this portable device for the detection of stroke that is based on decades of submarine warfare technology,” said Kieran J. Murphy, MD, director of research and deputy chief of radiology at the University of Toronto and University Health Network in Canada.

He said this technology could easily differentiate normal brain from life-threatening conditions, such as hematoma and hemorrhage. “For example, when a physician suspects stroke, time is of the essence; doctors could use the system to determine treatment that needs to begin immediately,” Murphy said in a statement.

The device’s continuous monitoring capability—unique in neurodiagnostics—will allow immediate detection of changes in a patient’s condition. In addition to its being ideal for field ER, ambulance, or military use, the researchers’ hope is for the technology to be adapted and used in other areas of acute care, such as open heart surgery (where stroke is an ever-present concern), in other vascular indications elsewhere in the body, and in monitoring the progression of disease for drug efficacy.

“Stroke is the third leading cause of death in the United States and the leading cause of disability,” Murphy said. And, stresses Murphy, “time to diagnosis is critical to improving patient outcomes; time is brain.”

“The system is very simple in principle, yet it yields exceedingly rich data,” said Murphy. He explained that the device’s basis in submarine technology means it works to measure a patient’s complex brain pulsations and to provide information on the type and location of an abnormality in many of the same ways as sonar works on submarines.

Both use an array of sensors to measure movement and generate signals to be processed and analyzed, matching the signals to objects or conditions. “As sonar sorts out whales and other objects from vessels, the device sorts out cerebral abnormalities such as aneurysms, arteriovenous malformations, ischemic strokes, and traumatic brain injury from normal variations in physiology,” noted Murphy.

Traditionally in transcranial ultrasound, the thinner areas of the skull are used as “windows” through which ultrasound can “see” or “listen,” said Murphy. This system does not rely on these “windows.”

It measures the movement of the skull (acceleration) to separate confounding acoustic signals from the motion created by the in-rushing blood flow in this way: blood flows into the brain during each pulse and a pressure wave emanates from the vessels outward in all directions. The wave encounters the skull and accelerates it. The device measures the acceleration and records this complex waveform with a time synchronized high-resolution digitizer, explained Murphy.

In a 40-patient proof-of-principle trial, the patients—16 men and 24 women—with a wide variety of cerebrovascular conditions, including intracerebral hemorrhage, subarachnoid hemorrhage, intracranial aneurysms, AVMs, ischemic stroke and transient ischemic attack, were studied. The team’s algorithms were able to separate normal from all other conditions, to separate all patients with a specific condition into their own category, and to provide information about the location of the abnormality.

Initial blood vessel models were used to identify data signatures that were subsequently verified on patients in the clinic. The interventional radiologists said that, as they continue to increase their signature library, their expectation is that the location capability, as well as the capacity to detect other neurologic conditions with a high degree of sensitivity and specificity, will also increase.

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