Universal HCV Screening During Pregnancy Is Cost-effective
Researchers calculate universal HCV screening of pregnant women would be cost-effective in the US, including in states with low HCV prevalence.
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Glecaprevir/Pibrentasvir Unaffected by Acid-Reducing Drugs for Hepatitis C
Analysis of multiple studies demonstrates glecaprevir/pibrentasvir pangenotypic HCV efficacy despite concurrent gastric acid-reducing drugs.
Anxiety, Depression Contribute to Multiple Sclerosis Impaired Cognition
Anxiety and depression each contribute to impaired cognition in patients with MS and other immune-mediated disorders, a new study shows.
Liver Cancer Risk Not Increased with Pre-Transplant Antiviral
Direct-acting antiviral treatment of HCV prior to liver transplant does not increase pre-transplant liver cancer progression or post-transplant recurrence.
Behavior Model Predicts When Patients Decline Multiple Sclerosis Treatment
Behavioral model predicts when MS patients decline treatment for delayed or insufficient benefit, and the probability and severity of side effects.
Direct-Acting Antivirals for HCV Reduce Mortality, Liver Cancer
The first prospective, longitudinal study of direct-acting antivirals for HCV finds that treatment reduces risks of all-cause mortality and liver cancer.
Novel Method Clears Hepatitis C from Donor Lungs
A novel method to inactivate HCV in donor lungs could allow additional transplants without post-transplant antiviral treatment.
HCV Treatment Efficacious for Associated Cryoglobulinemia Vasculitis
Successful HCV treatment with direct-acting antivirals provides long-term efficacy in resolving HCV-associated cryoglobulinemia vasculitis.
Analysis Favors Universal HCV Screening over Current Guidelines
Universal screening for HCV infection is projected to be cost effective and provide greater benefit than the currently recommended birth cohort screening.
OxyContin Abuse Deterrent Formulation Linked to HCV Surge
Reformulation of OxyContin to prevent it being dissolved and injected prompted switching to heroin and a surge in hepatitis C infections.
Higher Adherence to Less Frequently Prescribed Poststroke Antiepileptic
Largest observational study on antiepileptic treatment for poststroke epilepsy finds highest adherence to a less frequently prescribed drug.
Hepatologist Urges Appropriate Hepatitis C Post-Cure Care
Despite virologic cures of hepatitis C with direct-acting antivirals, post-cure care is necessary to prevent liver disease progression and manage complications.
Antiepileptic Dose Delays Associated with Worse Outcomes
A delay in giving the first dose of an antiepileptic for pediatric status epilepticus is common and associated with increased seizure duration.
App Aids in Diagnosing Pediatric Epilepsy
A prediction model helps determine the probability of childhood epilepsy in first consultation after a paroxysmal event.
Reviewers Consider the Current State of HCV Host-Targeting Agents
New host-targeting agents might help to overcome challenges in treating hepatitis C that remain, despite success with direct-acting antivirals.
New Hepatitis C Strains Could Harm World Eradication Goals
Three newly discovered strains of HCV genotype 7 in Africa, and a genotype 8 in India, complicate the World Health Organization's goal to eradicate HCV.
Hepatitis C Prevalent in Less Than 1% of US Population
Novel epidemiological approach accounting for persons with undiagnosed HCV shows half of cases in US are in 9 states, including 5 in Appalachia.
Noninvasive Tests Help ID Seizure Site in Children with Focal Epilepsy
A noninvasive and age-specific test could facilitate surgery for focal epilepsy in children.
Mapping Core Hepatitis C Areas Improves Targeted Treatment
Mapping techniques for tracking sexually transmitted bacterial disease can also identify core areas of HCV infection to guide treatment interventions.
Treating HCV in Addiction Patients Receiving Opioid Substitution Therapy
A series of recently presented studies support the notion of treating hepatitis C in patients already on opioid substitution therapy.
Addressing Stigma That Limits PrEP Use for HIV
Canadian investigators identified the role of media in both promulgating and mitigating stigma of PrEP for preventing HIV transmission.
Hepatitis C Genotype 3 Treated with Shortened Glecapravir/Pibrentasvir
Analysis of data from phase 2 and 3 trials supports an HCV genotype 3 indication for glecaprevir/pibrentasvir, and confirms its efficacy over 8 weeks.
Hepatitis C Extrahepatic Manifestations Reduced by Sustained Virologic Response
Sustained virological response with the treatment of HCV infection is associated with reduced mortality from extrahepatic complications, accoridng to a new study.
ADHD Associated with Prenatal Exposure to Valproate
Prenatal exposure to the antiepileptic drug valproate is associated with increased risk for ADHD independent of its link to congenital malformations.
A Correct, But Subtherapeutic Antiepileptic Dose Can Be Remedied
Antiepileptic drug levels that remain subtherapeutic—despite the correct dose and proper adherence—can improve with adjustment for pharmacokinetics.
Treating Hepatitis C Linked to Reduced Parkinsonism
A large Asian population study supports the link between HCV and parkinsonism in that region, and associated treating HCV with reduced risk.
New Pre-Med Protocol Improves Ocrelizumab Treatment for Multiple Sclerosis
Common infusion-associated adverse reactions with ocrelizumab for multiple sclerosis were substantially reduced with strategic premedication.
Transcranial Stimulation at Home Reduces Fatigue in Multiple Sclerosis
A sham-controlled trial demonstrated that a novel at-home administration of transcranial stimulation reduced fatigue in multiple sclerosis.
Epilepsy Characterized as Congenital Heart Disease Complication
Higher incidences of epilepsy in children with congenital heart disease prompted a neurocardiology team to call for increased perioperative EEG monitoring.
HIV Patient Reports Show Increased Physician Referral to ART
The CDC found that "provider-advised deferral" of HIV antiretroviral therapy occurring less, but that US still far from goal of universal prescribing.