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Antithrombotic Therapy in Patients with Atrial Fibrillation and Chronic Kidney DiseaseThe presence of chronic kidney disease (CKD) in patients with atrial fibrillation increases the risk of stroke and thromboembolism (TE) as well as the risk of bleeding, thus complicating their treatment. In this context, it has been suggested that CKD should be included in the CHA2DS2-VASc (Congestive heart failure; Hypertension; Age ≥75 years; Diabetes mellitus; previous Stroke, transient ischemic attack, or thromboembolism; Vascular disease; Age 65 to 74 years; Sex category) score.
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Doctors, Go Back to SchoolIn low-income areas where educational and career opportunities are limited, the AMA's Doctors Back to School Program works to give students a vision of something bigger.
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How Could I Help this Patient?Diana Farid and her 18-yr-old patient shared names of Middle-Eastern origin. Beyond that, they had little in common.
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Is warfarin a safe alternative to aspirin in elderly patients with atrial fibrillation?We recruited 973 patients (mean age, 81 years) with atrial fibrillation from the primary care setting and randomly assigned them to receive anticoagulation with warfarin or aspirin.
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Revolutionary Techniques in Neurosurgery: A Q&A with Ravish Patwardhan, MDRavish Patwardhan, MD, is the founder and director of the Comprehensive Neurosurgery Network (www.brainandspinecare.com), which "specializes in minimally invasive techniques for treating brain and spine problems." Patwardhan has more than 12 years of experience in the neurosurgery industry and has published several peer-reviewed studies on brain trauma, tumors, epilepsy, and spinal procedures. He is also a frequent speaker on the latest treatments and advances in brain and spinal surgeries.
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Patent foramen ovale closure for stroke prevention: A myriad of unanswered questionsMigraines, including those with aura, are common and generally benign, affecting between 10% and 15% of the population.
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Matthew Nudy, MD: Balancing the Benefits and Risk of Intensive Blood Pressure ControlMatthew Nudy, MD, discusses a trio of meta-analyses examining the effects of intensive blood pressure control on various targets.
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Wall Street Journal Op-Ed: Trying to Save Lives in Port-Au-PrinceA lot of amputees and the paralyzed will need lifelong care.
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Late events, less use of drug-eluting stents?The study by Handke et al focuses on one of the most controversial areas of interventional cardiology—the clinical downside of treatment with drug-eluting stents (DES).
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Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.
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Metoprolol for the prevention of vasovagal syncopeIn the Prevention of Syncope Trial, we evaluated whether beta-blocker treatment with metoprolol was beneficial for the treatment of patients with vasovagal syncope. Results showed little evidence that metoprolol was effective in reducing the burden of syncopal symptoms. In a substudy analysis, neither age nor response to isoproterenol was useful in selecting which patients might benefit from metoprolol.
