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Large-scale clinical epidemiology of stable angina in women and men

We performed a whole-country study using linked health care records in Finland and showed that stable angina as the initial symptomatic manifestation of coronary disease occurs as frequently in women as it does in men. Among easily recognized subgroups, the absolute rates of prognostic outcomes were similarly high in women and men.

ARBs and the Impact of Worsening Renal Function in Heart Failure Patients With Preserved EF

Worsening renal function over time is associated with poorer outcomes in patients with acute and chronic HF. Although this association is established in patients with reduced ejection fraction, there are no data about the relationship between WRF and outcomes in HF patients with preserved ejection fraction.

The 2009 Breast Cancer Symposium

Breast cancer requires an interdisciplinary management plan, and at various points in treatment, care shifts between surgeon, medical oncologist, and radiation oncologist. In addition, radiologists and pathologists remain critical players in the appropriate diagnosis, work-up, and staging of the disease.

Mortality of patients with diabetes mellitus and acute myocardial infarction

We evaluated trends in the treatment and mortality of patients with and without diabetes mellitus and acute myocardial infarction over the last decade. Despite improvements in the provision of evidence-based care, patients with diabetes did not derive improvements in long-term survival.

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A misleading ECG

A 10-year-old girl was brought to her primary care provider by her mother because she complained of chest pain earlier that morning. She also reported abdominal pain and nausea.

Overcoming Resistance to Catheter-Directed Therapy in Submassive Pulmonary Embolism

The optimal treatment of submassive pulmonary embolism (PE) remains controversial, despite growing evidence to support a role for catheter-directed therapy in carefully selected patients.

Symptomatic carotid plaques and ischemic symptoms

We assessed the histologic features of 526 carotid plaques from consecutive patients undergoing endarterectomy for symptomatic carotid stenosis and found a high prevalence of coronary-type plaque instability, with strong correlations between macrophage infiltration and both cap rupture and time since stroke. Temporal trends were much weaker after a transient ischemic attack than after a stroke, with a tendency for plaque features to persist for a longer period, suggesting heterogeneity in the underlying pathological mechanisms.

Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?

The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.

Preempting Stage A Heart Failure In Primary Care

Barton-Maxell details the importance of caring for stage A heart failure patients in the primary care setting.

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