Nephrology

The use of GLP-1 receptor agonists was associated with lower all-cause mortality and lower sepsis- and infection-related mortality compared to DPP-4 inhibitors.

The complete response letter from the FDA cited a lack of effectiveness in slowing the loss of kidney function in patients with Alport syndrome.

The treatment was comparable to darbepoetin alfa in treating patients with chronic kidney disease who were not undergoing dialysis.

Patients who receive a solid organ transplant and develop CDI are at an increased risk for an acute kidney injury.

The adjusted change in 24-hour systolic blood pressure from baseline to 12 weeks was −11.0 mm Hg in the chlorthalidone group and −0.5 mm Hg in the placebo group.

The treatment resulted in a significant reduction of proteinuria from baseline in 34% of trial participants.

Patients with sickle cell disease often suffer from acute kidney injuries and chronic kidney disease.

The DCRM Task Force recommendations were described as first-of-its-kind guidance for patients with overlapping diabetic, cardiorenal and metabolic disease.

Data show hemoglobin level of SGLT2 inhibitor users were higher at an eGFR above >15 mL/min/1.73m2 compared to non-users.

After 1 year, 37% of patients had died and 65% of patients were readmitted to the hospital.

There was a 135% reduction in platelet inhibition observed within 5-10 minutes following bentracimab infusion.

The least selected attributes were food and medication restrictions and A1c lowering followed by risk of diabetic ketoacidosis, risk of genital infection, and the avoidance of severe hypoglycemia.

The adjusted change in 24-hour systolic blood pressure was -11.0 mm Hg in the chlorthalidone group and -0.5 mm Hg in the placebo group.

Though immunogenicity responses to the vaccine were lower in dialysis patients, the lower response rate was less apparent in second doses.

Patients with Crohn's disease often also suffer from kidney dysfunction.

The new PDUFA date for Nefecon will be December 15, 2021.

Updates to the ADA Standards of Medical Care emphasize the utility of SGLT2 inhibitors and GLP-1 agonists. Yet, initiation is lacking from prescribers.

Investigators urge patients undergoing hemodialysis to adhere to their COVID-19 vaccination schedules, as data show a low antibody response.

Now that the agent shows benefit in mitigating comorbid risks, the expert advocates for more timely diagnoses and treatment initiation.

Incidence of death from cardiovascular causes was lower in the finerenone group (458 of 3686 patients) compared to the placebo group (519 of 3666 patients).

The new SLE test enhances specificity without sacrificing sensitivity.

The FDA noted the extent of the treatment effect of tenapanor is of unclear clinical significance, despite evidence of efficacy.

The priorities established by a panel of experts are designed to improve efficacy and equity in kidney research and care.

The treatment met all 5 primary efficacy endpoints as part of the ASCEND program.

The FDA Cardiovascular and Renal Drugs Advisory Committee cited concerns over an increase in thrombotic events.

Dennis Bruemmer, MD discusses new agents and perspectives on care in treating patients with type 2 diabetes at high risk of CV, renal complications.

Data show event rates varied two-fold across regions, with risk reduction of T2D and CKD events across geographic regions without heterogeneity.

The study shows a reduction in hemoglobin and a reduced risk of hypoglycemia in participants.

Data show a 38% reduction in T2D incidence with dapagliflozin compared to placebo in patients with CKD.

Data show 66% of healthcare professionals reported greater confidence in prescribing SGLT2i, while 55% reported greater confidence in prescribing GLP-1.