Caffeine Improves Nocturnal
Hypoglycemia in Diabetics
A total of 19 patients with long-standing type 1 diabetes were randomized to receive caffeine or placebo during continuous glucose sensing and monitoring of autonomic function. The mean duration of nocturnal hypoglycemia was 49 minutes with caffeine and 132 minutes with placebo (P = .035). The shortened duration of nighttime hypoglycemia was attributed to a decrease
in the number of episodes of moderate hypoglycemia at the expense of mild hypoglycemic
episodes. There was no correlation between hypoglycemic events and reduced heart rate variability (Diabetes Care. 2005;28:1316-1320).