Publication
Article
H Pylori Infection Linked to Low
Esophageal Cancer Risk
The nonexistence the Helicobacter pylori infection, regardless of cigarette smoking or
body mass index, was associated with an increased risk of the development of
esophageal adenocarcinoma based on data on 128,992 patients who had a multiphasic
health checkup (MHC) during 1964-1969; of these, 52 patients developed esophageal
adenocarcinoma during follow-up. On the basis of age at the MHC, sex, race, and the
date and site of the MHC, 3 control patients were matched against 3 case
patients. Serum samples were tested for immunoglobulin (Ig) G antibodies to H
pylori and to the H pylori CagA protein. Patients with H pylori infection were less
likely than those without H pylori infection to develop esophageal adenocarcinoma. A
significant association was found in case patients and control patients aged <50 years
at the MHC. Among those with H pylori