H Pylori Infection Linked to Low Esophageal Cancer Risk

H Pylori Infection Linked to Low

Esophageal Cancer Risk

The nonexistence the Helicobacter pylori infection, regardless of cigarette smoking or

body mass index, was associated with an increased risk of the development of

esophageal adenocarcinoma based on data on 128,992 patients who had a multiphasic

health checkup (MHC) during 1964-1969; of these, 52 patients developed esophageal

adenocarcinoma during follow-up. On the basis of age at the MHC, sex, race, and the

date and site of the MHC, 3 control patients were matched against 3 case

patients. Serum samples were tested for immunoglobulin (Ig) G antibodies to H

pylori and to the H pylori CagA protein. Patients with H pylori infection were less

likely than those without H pylori infection to develop esophageal adenocarcinoma. A

significant association was found in case patients and control patients aged <50 years

at the MHC. Among those with H pylori