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Spotlight -

This Year In Medicine 2025

Opinion|Videos|May 23, 2024

Novel Cardiac Myosin Inhibitors Targeting Obstructive Hypertrophic Cardiomyopathy's Root Cause

Author(s)Anjali Tiku Owens, MD

Anjali Tiku Owens, MD, examines the unmet needs in treating obstructive hypertrophic cardiomyopathy (oHCM) and explores how novel Cardiac Myosin inhibitors (CMIs) address the root cause of the condition.

Episodes in this series

Video 1 - "Novel Cardio Myosin Inhibitors Targeting Obstructive Hypertrophic Cardiomyopathy's Root Cause "

EP. 1 Novel Cardiac Myosin Inhibitors Targeting Obstructive Hypertrophic Cardiomyopathy's Root Cause

Video 2 - "Lessons from EXPLORER-HCM: Unveiling CMIs' Potential in oHCM Treatment "

EP. 2 Lessons from EXPLORER-HCM: Unveiling CMIs' Potential in oHCM Treatment

Video 3 - "Aligning With 2023 ESC Guidelines in oHCM Treatment"

EP. 3 Aligning With 2023 ESC Guidelines in oHCM Treatment

Video 4 - "Mavacamten in oHCM: Navigating the REMS Program for Safe, Optimal Outcomes "

EP. 4 Mavacamten in oHCM: Navigating the REMS Program for Safe, Optimal Outcomes

Video 5 - "Real-World Insights: Navigating Cardiac Myosin inhibitors in Practice" - Featuring 1 KOL

EP. 5 Real-World Insights: Navigating Cardiac Myosin inhibitors in Practice

The treatment of obstructive hypertrophic cardiomyopathy (oHCM) has a high level of unmet needs, can you discuss these with us?

How do novel cardiac myosin inhibitors (CMIs) target the underlying cause of oHCM?

2. What has the impact of CMI’s been on the management of oHCM?

Complements (first line) standard of care
Addresses the root cause of oHCM
Narrowing the substantial gap between effective medical therapy and the more definitive invasive treatments like alcohol septal ablation and surgical myectomy.

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