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This Year In Medicine 2025

Opinion|Videos|May 23, 2024

Lessons from EXPLORER-HCM: Unveiling CMIs' Potential in oHCM Treatment

Author(s)Anjali Tiku Owens, MD

A expert cardiologist delves into the insights gained from clinical trials assessing Cardiac Myosin inhibitors (CMIs) for the treatment of obstructive hypertrophic cardiomyopathy (oHCM), with a particular focus on the EXPLORER-HCM trial, which investigated the efficacy and safety of mavacamten in managing oHCM.

Episodes in this series

Video 1 - "Novel Cardio Myosin Inhibitors Targeting Obstructive Hypertrophic Cardiomyopathy's Root Cause "

EP. 1 Novel Cardiac Myosin Inhibitors Targeting Obstructive Hypertrophic Cardiomyopathy's Root Cause

Video 2 - "Lessons from EXPLORER-HCM: Unveiling CMIs' Potential in oHCM Treatment "

EP. 2 Lessons from EXPLORER-HCM: Unveiling CMIs' Potential in oHCM Treatment

Video 3 - "Aligning With 2023 ESC Guidelines in oHCM Treatment"

EP. 3 Aligning With 2023 ESC Guidelines in oHCM Treatment

Video 4 - "Mavacamten in oHCM: Navigating the REMS Program for Safe, Optimal Outcomes "

EP. 4 Mavacamten in oHCM: Navigating the REMS Program for Safe, Optimal Outcomes

Video 5 - "Real-World Insights: Navigating Cardiac Myosin inhibitors in Practice" - Featuring 1 KOL

EP. 5 Real-World Insights: Navigating Cardiac Myosin inhibitors in Practice

What have we learned from clinical trials evaluating CMI’s for oHCM? Hutt et al 2024

Mavacamten: Outcomes; focused on feel and function Olivotto et al 2020, Maron et al 2023
Longer-term outcomes of the VALOR-HCM RCT Desai et al 2023
MAVA-LTE
Aficamten: phase 2 REDWOOD-HCM soon to be completed, phase 3 trial SEQUIOA-HCM. Masri et al 2022, Maron et al 2023

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