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Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?

The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.

Preempting Stage A Heart Failure In Primary Care

Barton-Maxell details the importance of caring for stage A heart failure patients in the primary care setting.

Guard Against Home Equity Loan Dangers

EHR Usability: Addressing the "(I Can't Get No) Satisfaction" Sentiment

Techniques to identify and address EHR usability challenges.

Warfarin versus aspirin for stroke prevention in the elderly study: Putting fears to rest

The article by Mant and colleagues concerning the Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) study is a welcomed addition to the now vast literature regarding the relative benefits of warfarin anticoagulation in patients with atrial fibrillation.

Localized Chemotherapy Delivery: A Brief Review

The concept of treating malignancies using a regional approach originated in 1950, when Klopp and associates began to infuse nitrogen mustard into the arterial supply of various neoplasms.

Intracranial hemorrhage in atrial fibrillation: Is there a racial/ethnic difference?

We evaluated a multiethnic cohort of subjects with nonrheumatic atrial fibrillation hospitalized over a 6-year period to determine the racial and ethnic differences in the risk of intracranial hemorrhage (ICH) and the effect of warfarin treatment on ICH risk. Treatment with warfarin was associated with a 2-fold greater risk of ICH in whites, a 4- to 5-fold greater risk in both blacks and Hispanics, and a 15-fold greater risk in Asians. After adjusting for established stroke risk factors and warfarin use, Asians were 4 times as likely as whites to have ICH, whereas blacks and Hispanics were twice as likely.

Prognostic value of multislice computed tomography coronary angiography

We evaluated 100 subjects who underwent multislice computed tomography (MSCT) to assess the presence and severity of coronary artery disease (CAD) and to determine the occurrence of coronary events (including cardiac death, nonfatal myocardial infarction, unstable angina requiring hospitalization, and revascularization) over a follow-up period of 16 months.

Smoking Cessation Counseling in Lung Cancer Screening Programs

Most programs offer smoking cessation counseling as part of the shared decision making visit and throughout the program. Some LCS programs also order pulmonary function studies for new patients to provide an overall picture of lung health.

Diabetes-related poor outcomes in chronic heart failure: Complex interactions with sex and age

This propensity-matched study, in which patients with and without diabetes were well balanced in all measured baseline characteristics, including traditional risk factors and comorbidities, found that diabetes was associated with increased mortality and hospitalization in ambulatory patients who had chronic, mild-to-moderate heart failure and were receiving angiotensin-converting enzyme inhibitors. These findings also highlight the sex- and age-related variations in the effect of diabetes in these patients.

A Generation of Debt, Part III: Mature Families and Empty Nesters

Combining warfarin and antiplatelet therapy after coronary stenting

We conducted an observational study to compare singleantiplatelet therapy with dualantiplatelet therapy among patients requiring long-term warfarin therapy after coronary stenting. Results showed that there was no difference in mortality or myocardial infarction between the 2 treatment regimens at 6 months, with no excess in-hospital bleeding; however, larger trials are needed to determine firm recommendations.

Management of multivessel CAD in ACS patients: Do not leave for later what you can finish today

Although multivessel coronary artery disease (CAD) is commonly encountered in patients with acute coronary syndrome (ACS), no randomized controlled trials have evaluated the effi cacy of singlevessel percutaneous coronary intervention (PCI) versus multivessel PCI.