Authors

Double infarct syndrome: Simultaneous subacute ST-segment elevation myocardial infarction involving the right coronary and the left circumflex arteries

Ruptured or vulnerable plaques exist not only at the culprit lesion but also in the whole coronary artery in some acute coronary syndrome (ACS) patients.Goldstein et al found features of instability of nonculprit plaques in nearly 40% of patients by angiography,1 whereas actual rupture in a remote site other than the angiographic culprit lesion was found in approximately 13% to 79% of cases when evaluated by intravascular ultrasound.

Intracranial hemorrhage in atrial fibrillation: Is there a racial/ethnic difference?

We evaluated a multiethnic cohort of subjects with nonrheumatic atrial fibrillation hospitalized over a 6-year period to determine the racial and ethnic differences in the risk of intracranial hemorrhage (ICH) and the effect of warfarin treatment on ICH risk. Treatment with warfarin was associated with a 2-fold greater risk of ICH in whites, a 4- to 5-fold greater risk in both blacks and Hispanics, and a 15-fold greater risk in Asians. After adjusting for established stroke risk factors and warfarin use, Asians were 4 times as likely as whites to have ICH, whereas blacks and Hispanics were twice as likely.

Smartphones Moving to the Front Line of Mobile Technology for Physicians

Traditionally, physicians have relied on textbooks, conferences, and, more recently, the Internet to keep abreast of the latest clinical data and support clinical decision-making

Mortality of patients with diabetes mellitus and acute myocardial infarction

We evaluated trends in the treatment and mortality of patients with and without diabetes mellitus and acute myocardial infarction over the last decade. Despite improvements in the provision of evidence-based care, patients with diabetes did not derive improvements in long-term survival.

Chronic diuretic use and increased mortality and hospitalization in heart failure

Diuretic use is associated with activation of neurohormones and disease progression in heart failure. Yet, diuretics are commonly prescribed, although little is known about their long-term effects. We performed a study based on propensity score matching, which indicated that in subjects with ambulatory, chronic, mild-to-moderate heart failure, diuretic use was associated with increased mortality and hospitalization. These findings call into question the wisdom of using long-term diuretic therapy in heart failure patients who are asymptomatic or minimally symptomatic.

Study All Angles of a Cash Balance Plan

Prediction of coronary artery disease in patients with diabetes and albuminuria

We developed a set of equations to predict the risk or probability of developing coronary artery disease (CAD) in 10 years among American Indians. The equations are based on the significant risk factors identified in the Strong Heart Study, a longitudinal study of cardiovascular disease in American Indians. The equations can be used in patient education and to evaluate the efficacy of CAD prevention and intervention programs.

Insomnia Medications for Older Adults: A Double-Edged Solution?

Crowdsourcing Brings Researchers and the Community Together to Cure HIV

Misinformation about clinical research, mistrust between scientists and the community, and HIV-related stigma often impede efforts to find an HIV cure.

The effect of diabetes on death and hospitalization in heart failure patients

In the cohort study conducted by Ahmed and colleagues, the investigators assessed whether diabetes was associated with worse outcomes in heart failure regardless of the associated risk factors and comorbidities.

Late diagnosis of a congenital coronary anomaly

A 64-year-old woman with a history of atrial fibrillation, hypertension, and sarcoidosis presented to the emergency department with chest pain. After a positive stress test, a coronary angiogram was performed, which showed normal coronary arteries except for an anomalous take-off of the left circumflex artery from the right coronary cusp.