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Incidence of death and MI associated with stopping clopidogrel after ACS

Rates of death and myocardial infarction were assessed for a national sample of acute coronary syndrome patients after stopping clopidogrel. In the first 90 days after stopping treatment, patients experienced a nearly twofold increased risk of adverse events compared with subsequent follow-up intervals for patients treated medically without stents and for patients treated with coronary stents. This suggests a possible clopidogrel rebound effect, but additional studies are needed to support this hypothesis and to identify strategies to reduce early events after clopidogrel cessation.

Hyperglycemia and platelet function in diabetic patients: Relevance to acute myocardial ischemia and infarction

Diabetic patients with acute coronary syndromes are at higher risk for mortality, even if they have ST-segment elevation myocardial infarction. Diabetic patients with unstable angina/non–Q-wave infarction have impaired platelet responsiveness to nitric oxide, a physiological anti-aggregating autocoid. The extent of this impairment depends on the degree of hyperglycemia. Rapid correction of hyperglycemia with infused insulin restores responsiveness to nitric oxide, thus ameliorating platelet dysfunction.

Providing Obstetric Care for Women with a History of Sexual Trauma

We asked women with a history of sexual trauma about their pregnancy and childbirth experiences and used their experiences and insight to inform practice recommendations.

Invest to Win the World Series, Not the Game

Treatment with Alemtuzumab Might Be ‘Resetting' the Immune System in Patients with Relapsing-Remitting Multiple Sclerosis

Study results indicate that treatment with alemtuzumab reduces focal inflammation, with durable effects that may be due to the distinct pattern of lymphocyte depletion and repopulation after treatment.

Oxycodone Shortage Leaves Pharmacies in Short Supply--March 2009

A large-scale recall of oxycodone is a real pain for pharmacies and patients.

Upfront thrombus aspiration during PCI may improve outcomes

NEW YORK (Reuters Health) - Upfront thrombus aspiration during percutaneous coronary intervention (PCI) may improve outcomes in patients with ST-segment-elevation acute myocardial infarction (STEMI), according to a report in the August Journal of the American College of Cardiology: Cardiovascular Interventions.

Prevalent atherosclerosis-Choose your biomarker

Circulating biomarkers have been used in cardiovascular medicine as predictors of incident or prevalent disease.

Syncope from ventricular tachycardia secondary to methadone use

Methadone HCI (Diskets, Dolophine, Methadose) is a synthetic opioid that has been used widely in the United States for the management of heroin addiction Treatment of opioid dependence has been shifting gradually from the older US Food and Drug Administration (FDA) inspection program, ...

Grasp the Super IRA's Asset Protection