News|Articles|December 2, 2025

2025 in Hepatology: New MASLD Therapies, HBV Updates, and More

Author(s)Hersh Shroff, MD, MPA, Zobair Younossi, MD, MPH, Wei Zhang, MD, PhD

Recent advancements in hepatology highlight new medications for metabolic dysfunction and liver diseases, promising improved patient outcomes and treatment options.

2025 has marked a clear turning point in hepatology, bringing advances that are reshaping both the scientific landscape and everyday clinical practice. After years defined by limited therapeutic options and slow-moving pipelines, this year delivered transformative progress, from the long-awaited arrival of effective pharmacologic treatments for MASLD/MASH to renewed innovation in viral hepatitis, cholestatic liver diseases, portal hypertension, and alcohol-associated liver disease.