March 2026 brought a wave of regulatory updates and emerging therapeutic data across the allergy and immunology space, spanning anaphylaxis management, food allergy desensitization, hereditary angioedema (HAE), systemic mastocytosis, and chronic rhinosinusitis with nasal polyps (CRSwNP). Several developments centered on improving access to emergency therapies and accelerating disease-modifying approaches for IgE-mediated allergy and mast cell–driven conditions. Key updates from the month highlighted advances in noninvasive treatment options, RNA-based therapeutics, and targeted inhibitors with rapid onset of action.