Digestive Disease Week (DDW) 2026 featured a wave of new data across inflammatory bowel disease (IBD), eosinophilic esophagitis (EoE), and irritable bowel syndrome (IBS), with investigators highlighting advances in disease modification, long-term durability, and emerging therapeutic mechanisms. From phase 3 fistulizing Crohn disease data to early evidence supporting varenicline in IBS, this year’s meeting delivered several studies with potential implications for clinical practice.