News|Articles|July 23, 2026

Epinephrine Nasal Spray Is Here. Updated Anaphylaxis Guidelines Aren't.

Author(s)Chelsie Derman, David Golden, MD, Marcus Shaker, MD

Fact checked by: Tim Smith

Allergists explain what's settled about epinephrine nasal spray, what's not, and how to counsel patients before anaphylaxis guidelines catch up.

A patient who’s terrified of needles now has a legitimate needle-free option for treating anaphylaxis: epinephrine nasal spray (neffy), approved on August 9, 2024.¹However, if this patient were to ask whether the guidelines favor epinephrine nasal spray, the honest answer is not quite yet.