HFSA 2025 Preview: 8 Late-Breaking Studies to Know

The Heart Failure Society of America (HFSA) Annual Scientific Meeting returns September 27–30, 2025, in Minneapolis, Minnesota, bringing together leading investigators, clinicians, and industry to spotlight the latest advances in heart failure research and patient care.
This year’s late-breaking clinical science program underscores both the diversity and urgency of innovation across the field—from disease-modifying therapies in hypertrophic cardiomyopathy and amyloidosis, to novel agents for acute decompensation and cardiogenic shock, to precision-focused analyses that refine treatment strategies in HFpEF and HFrEF.

To help prepare for the meeting, our editorial team has compiled a list of 8 late-breaking clinical trials to know from the meeting, which are highlighted below.