Practice Pearls for the Management of SCD
A panel of experts in hematology discuss the future directions for sickle cell disease and share practice pearls for disease management.
Utility of Potential SCD Biomarkers in SCD Management
Matthew M. Heeney, MD, and Nirmish Shah, MD, hypothesize about the ability of emerging sickle cell disease biomarkers to assess risk-benefit and disease severity in patients.
Increasing Confidence in Emerging Therapies
Nirmish Shah, MD, and Matthew M. Heeney, MD, discuss the need for ongoing clinical trials and diversity in them to bolster data and improve provider confidence in emerging therapeutic options for sickle cell disease.
Role of Clinical Trial Endpoints and Metrics in SCD Therapies
Dr Elna Saah highlights the role of data longevity, clinical trial end points, and metrics when evaluating novel treatments for the management of sickle cell disease.
Role of Gene Therapy in SCD Management
Dr Matthew M. Heeney shares his hopes for the future of gene therapy in the management of patients with sickle cell disease.
Exploring Emerging Therapies and Their Potential for Curative Intent in SCD
Experts in hematology hypothesize about the potential for curative vs disease-modifying therapies in the management of sickle cell disease.
Current FDA-Approved Therapies for SCD Management
Matthew M. Heeney, MD, reviews the mechanism of action and the safety and efficacy data of FDA-approved therapies for the management of sickle cell disease.
Conversations Surrounding SCD Treatment Options
Nirmish Shah, MD, shares his advice for initiating conversations with patients about treatment options and selection criteria for sickle cell disease.
Exploring Patient-Reported Disease Burden and Unmet Needs
Nirmish Shah, MD; Elna Saah, MD; and Biree Andemariam, MD, highlight sickle cell disease burden through the lens of their patients and comment on unmet needs in disease management.
SCD: Unmet Needs, Prevalence, and Burden of Disease
An expert in hematology provides insight into the unmet needs, overall prevalence, and disease burden of sickle cell disease.
An Overview of Sickle Cell Disease (SCD)
Elna Saah, MD, provides an overview of sickle cell disease and comments on disease pathophysiology.
Impact of RBC Disorders on Patient QoL
Matthew M. Heeney, MD, leads a discussion on the impact of unhealthy RBCs and blood disorders on a patient’s quality of life.
Impact of Biochemical, Epigenetic, and Genetic Factors in RBC Health
Matthew M. Heeney, MD, and Elna Saah, MD, highlight the role of 2,3-disphosphoglycerate as well as epigenetic and genetic factors in RBC form and function.
Characteristics of an Unhealthy RBC
An expert in hematology provides an overview of the characteristics of an unhealthy RBC.
Role of Unhealthy RBCs in Blood Disorders
Dr Matthew M. Heeney reviews the characteristics of an unhealthy RBC and how they can lead to blood disorders.
Patient Conversations Regarding RBC Health
Biree Andemariam, MD, and Matthew M. Heeney, MD, comment on the importance of patient education in RBC health management and discuss how they initiate these conversations with patients.
Clinician Awareness of RBC Health and Related Laboratory Measurements
Dr Nirmish Shah shares his opinion surrounding the clinician awareness of RBC health metrics as well as diagnostic examinations, and Dr Elna Saah shares her insight into explaining these metrics to patients.
RBC Health Clinical Assessment
Dr Elna Saah leads a discussion on clinical and laboratory measures that can be utilized to determine RBC health.
Role of 2,3-disphosphoglycerate in RBCs
Matthew M. Heeney, MD, explores the role of 2,3-disphosphoglycerate in RBCs, highlighting the interplay of this compound with pyruvate kinase-R and hemoglobin.
RBC Biochemistry, Form, and Function
Nirmish Shah, MD, discusses the biochemical pathways within RBCs and their importance in facilitating a healthy RBCs form and function.
Overview of Red Blood Cell (RBC) Role in Oxygen Generation
Elna Saah, MD, reviews the role of red blood cells in oxygen transport and energy generation.
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