Healthcare systems are navigating unprecedented demands, especially in rare disease, where existing resources often struggle to keep pace with real-time clinical needs and the ongoing shift toward value-based care. In this conversation, Duane Clark, General Manager, Rare Disease at Sanofi, and Robert Hopkin, MD, Clinical Geneticist at Cincinnati Children’s Hospital Medical Center, discuss how the field is changing and how the Sanofi 1RARE model has grown to help meet these changes.