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September 24, 2008
Pharmacologic inhibition of the renin-angiotensin aldosterone system (RAAS) has become a widely accepted approach to lowering blood pressure (BP).
September 23, 2008
A patient's response to drugs may be influenced by many factors, including age, race, sex, ethnic background, metabolic phenotype, body fat content and distribution, and body size. Drug–drug and drug–disease interactions are also important.
September 22, 2008
The previous installment of this series on clinical research highlighted some important fundamentals in cohort studies and randomized controlled trials (RCTs). In this article, additional issues that are critical to the understanding of RCTs are discussed, including causal inference, the use of surrogate measures, and the principle of intention to treat (ITT).
Joseph Goldberg, MD: Treating Mixed Feature Depression
M. Katherine Shear, MD: Addressing Grief After a Loss
Larry Culpepper, MD: The Challenge of Treating BPD